MED14

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Cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
Identifiers
Symbol(s) CRSP2; CSRP; CRSP150; CXorf4; DRIP150; EXLM1; MED14; MGC104513; RGR1; TRAP170
External IDs OMIM: 300182 MGI: 1349442 HomoloGene: 22082
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9282 26896
Ensembl ENSG00000180182 ENSMUSG00000064127
Uniprot O60244 n/a
Refseq XM_001126052 (mRNA)
XP_001126052 (protein)		 NM_001048208 (mRNA)
NP_001041673 (protein)
Location Chr X: 40.39 - 40.48 Mb Chr X: 11.84 - 11.92 Mb
Pubmed search [1] [2]

Cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa, also known as CRSP2, is a human gene.[1]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.[1]

[edit] References

  1. ^ a b Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa.

[edit] Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. PMID 8710870. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Yoshikawa H, Fujiyama A, Nakai K, et al. (1998). "Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method.". Genomics 49 (2): 237–46. doi:10.1006/geno.1998.5246. PMID 9598311. 
  • Sun X, Zhang Y, Cho H, et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.". Mol. Cell 2 (2): 213–22. PMID 9734358. 
  • Ryu S, Zhou S, Ladurner AG, Tjian R (1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.". Nature 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412. 
  • Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.". Mol. Cell 3 (1): 97–108. PMID 10024883. 
  • Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.". Mol. Cell 3 (3): 361–70. PMID 10198638. 
  • Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.". Nature 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266. 
  • Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267. 
  • Hittelman AB, Burakov D, Iñiguez-Lluhí JA, et al. (1999). "Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins.". EMBO J. 18 (19): 5380–8. doi:10.1093/emboj/18.19.5380. PMID 10508170. 
  • Ge K, Guermah M, Yuan CX, et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.". Nature 417 (6888): 563–7. doi:10.1038/417563a. PMID 12037571. 
  • Malik S, Wallberg AE, Kang YK, Roeder RG (2002). "TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4.". Mol. Cell. Biol. 22 (15): 5626–37. PMID 12101254. 
  • Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lau JF, Nusinzon I, Burakov D, et al. (2003). "Role of metazoan mediator proteins in interferon-responsive transcription.". Mol. Cell. Biol. 23 (2): 620–8. PMID 12509459. 
  • Demirci FY, Ramser J, White NJ, et al. (2004). "Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4.". DNA Seq. 14 (2): 123–7. PMID 12825353. 
  • Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168. 
  • Wallberg AE, Yamamura S, Malik S, et al. (2004). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.". Mol. Cell 12 (5): 1137–49. PMID 14636573. 
  • Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676. 
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