MED12

From Wikipedia, the free encyclopedia

Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)

Identifiers

MED12; OPA1; CAGH45; HOPA; KIAA0192; TNRC11; TRAP230

External IDs

OMIM: 300188 MGI: 1926212 HomoloGene: 68441

Gene ontology
Molecular Function:	• receptor activity • protein binding • RNA polymerase II transcription mediator activity • ligand-dependent nuclear receptor transcription coactivator activity • vitamin D receptor binding • thyroid hormone receptor binding
Cellular Component:	• mediator complex • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • androgen receptor signaling pathway • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_005120 (mRNA)
NP_005111 (protein)

NM_021521 (mRNA)
NP_067496 (protein)

Location

Chr X: 70.26 - 70.28 Mb

n/a

Pubmed search

[1]

[2]

Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human gene.^[1]

[edit] References

^ Entrez Gene: MED12 mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae).

[edit] Further reading

Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. PMID 8710870.
Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. PMID 8724849.
Yamagata K, Takeda J, Menzel S, et al. (1996). "Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle.". Diabetologia 39 (6): 725–30. PMID 8781769.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Margolis RL, Abraham MR, Gatchell SB, et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain.". Hum. Genet. 100 (1): 114–22. PMID 9225980.
Philibert RA, King BH, Winfield S, et al. (1998). "Association of an X-chromosome dodecamer insertional variant allele with mental retardation.". Mol. Psychiatry 3 (4): 303–9. PMID 9702738.
Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.". Mol. Cell 3 (3): 361–70. PMID 10198638.
Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.". Nature 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.
Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
Philibert RA, Winfield SL, Damschroder-Williams P, et al. (1999). "The genomic structure and developmental expression patterns of the human OPA-containing gene (HOPA).". Hum. Genet. 105 (1-2): 174–8. PMID 10480376.
Joensuu T, Hämäläinen R, Yuan B, et al. (2001). "Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.". Am. J. Hum. Genet. 69 (4): 673–84. PMID 11524702.
Beyer KS, Klauck SM, Benner A, et al. (2002). "Association studies of the HOPA dodecamer duplication variant in different subtypes of autism.". Am. J. Med. Genet. 114 (1): 110–5. PMID 11840515.
Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.". Mol. Med. 8 (1): 56–64. PMID 11984006.
Ge K, Guermah M, Yuan CX, et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.". Nature 417 (6888): 563–7. doi:10.1038/417563a. PMID 12037571.
Zhou R, Bonneaud N, Yuan CX, et al. (2002). "SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex.". Nucleic Acids Res. 30 (14): 3245–52. PMID 12136106.
Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
Gwack Y, Baek HJ, Nakamura H, et al. (2003). "Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation.". Mol. Cell. Biol. 23 (6): 2055–67. PMID 12612078.
Kitano T, Schwarz C, Nickel B, Pääbo S (2004). "Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees.". Mol. Biol. Evol. 20 (8): 1281–9. doi:10.1093/molbev/msg134. PMID 12777533.