MECR

From Wikipedia, the free encyclopedia

Mitochondrial trans-2-enoyl-CoA reductase

PDB rendering based on 1zsy.

Available structures: 1zsy

Identifiers

Symbol(s)

MECR; CGI-63; FASN2B; NRBF1

External IDs

OMIM: 608205 MGI: 1349441 HomoloGene: 5362

Gene ontology
Molecular Function:	• zinc ion binding • oxidoreductase activity • trans-2-enoyl-CoA reductase (NADPH) activity
Cellular Component:	• mitochondrion
Biological Process:	• fatty acid biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001024732 (mRNA)
NP_001019903 (protein)

NM_025297 (mRNA)
NP_079573 (protein)

Location

Chr 1: 29.39 - 29.43 Mb

Chr 4: 131.12 - 131.14 Mb

Pubmed search

[1]

[2]

Mitochondrial trans-2-enoyl-CoA reductase, also known as MECR, is a human gene.^[1]

[edit] References

^ Entrez Gene: MECR mitochondrial trans-2-enoyl-CoA reductase.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Masuda N, Yasumo H, Furusawa T, et al. (1998). "Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors.". Gene 221 (2): 225-33. PMID 9795230.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703-13. PMID 10810093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Miinalainen IJ, Chen ZJ, Torkko JM, et al. (2003). "Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II.". J. Biol. Chem. 278 (22): 20154-61. doi:10.1074/jbc.M302851200. PMID 12654921.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.