MCRS1

From Wikipedia, the free encyclopedia

Microspherule protein 1

Identifiers

MCRS1; ICP22BP; MCRS2; MSP58; P78

External IDs

OMIM: 609504 MGI: 1858420 HomoloGene: 4622

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • nucleoplasm • cytoplasm
Biological Process:	• regulation of progression through cell cycle • protein modification process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001012300 (mRNA)
NP_001012300 (protein)

NM_016766 (mRNA)
NP_058046 (protein)

Location

Chr 12: 48.24 - 48.25 Mb

Chr 15: 99.07 - 99.08 Mb

Pubmed search

[1]

[2]

Microspherule protein 1, also known as MCRS1, is a human gene.^[1]

[edit] References

^ Entrez Gene: MCRS1 microspherule protein 1.

[edit] Further reading

Ren Y, Busch RK, Perlaky L, Busch H (1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120.". Eur. J. Biochem. 253 (3): 734–42. PMID 9654073.
Bruni R, Roizman B (1998). "Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells.". J. Virol. 72 (11): 8525–31. PMID 9765390.
Lin DY, Shih HM (2002). "Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration.". J. Biol. Chem. 277 (28): 25446–56. doi:10.1074/jbc.M200633200. PMID 11948183.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. PMID 14667819.
Song H, Li Y, Chen G, et al. (2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.". Biochem. Biophys. Res. Commun. 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. PMID 15044100.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Shimono K, Shimono Y, Shimokata K, et al. (2006). "Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.". J. Biol. Chem. 280 (47): 39436–47. doi:10.1074/jbc.M507356200. PMID 16186106.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hirohashi Y, Wang Q, Liu Q, et al. (2006). "p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability.". Oncogene 25 (35): 4937–46. doi:10.1038/sj.onc.1209500. PMID 16547491.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Davidovic L, Bechara E, Gravel M, et al. (2006). "The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons.". Hum. Mol. Genet. 15 (9): 1525–38. doi:10.1093/hmg/ddl074. PMID 16571602.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Du X, Wang Q, Hirohashi Y, Greene MI (2007). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription.". Exp. Mol. Pathol. 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID 17014843.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Zhang J, Liu J, Li X, et al. (2007). "The physical and functional interaction of NDRG2 with MSP58 in cells.". Biochem. Biophys. Res. Commun. 352 (1): 6–11. doi:10.1016/j.bbrc.2006.10.141. PMID 17109818.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.