MCM5

From Wikipedia, the free encyclopedia

MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)

Identifiers

MCM5; CDC46; MGC5315; P1-CDC46

External IDs

OMIM: 602696 MGI: 103197 HomoloGene: 4904

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • protein binding • ATP binding • DNA-dependent ATPase activity
Cellular Component:	• nucleus
Biological Process:	• regulation of progression through cell cycle • DNA replication • DNA replication initiation • transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006739 (mRNA)
NP_006730 (protein)

NM_008566 (mRNA)
NP_032592 (protein)

Location

Chr 22: 34.13 - 34.15 Mb

Chr 8: 78.01 - 78.02 Mb

Pubmed search

[1]

[2]

MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae), also known as MCM5, is a human gene.^[1]

The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.^[1]

[edit] References

^ ^a ^b Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae).

[edit] Further reading

Burkhart R, Schulte D, Hu D, et al. (1995). "Interactions of human nuclear proteins P1Mcm3 and P1Cdc46.". Eur. J. Biochem. 228 (2): 431–8. PMID 7705359.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Hu B, Burkhart R, Schulte D, et al. (1994). "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.". Nucleic Acids Res. 21 (23): 5289–93. PMID 8265339.
Paul R, Hu B, Musahl C, et al. (1996). "Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.". Cytogenet. Cell Genet. 73 (4): 317–21. PMID 8751386.
Ishimi Y, Ichinose S, Omori A, et al. (1996). "Binding of human minichromosome maintenance proteins with histone H3.". J. Biol. Chem. 271 (39): 24115–22. PMID 8798650.
Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.". J. Biol. Chem. 272 (16): 10928–35. PMID 9099751.
Tsuruga H, Yabuta N, Hashizume K, et al. (1997). "Expression, nuclear localization and interactions of human MCM/P1 proteins.". Biochem. Biophys. Res. Commun. 236 (1): 118–25. doi:10.1006/bbrc.1997.6865. PMID 9223437.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Zhang JJ, Zhao Y, Chait BT, et al. (1999). "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation.". EMBO J. 17 (23): 6963–71. doi:10.1093/emboj/17.23.6963. PMID 9843502.
Ohtani K, Iwanaga R, Nakamura M, et al. (1999). "Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F.". Oncogene 18 (14): 2299–309. doi:10.1038/sj.onc.1202544. PMID 10327050.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
DaFonseca CJ, Shu F, Zhang JJ (2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma.". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. doi:10.1073/pnas.061487598. PMID 11248027.
Going JJ, Keith WN, Neilson L, et al. (2002). "Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa.". Gut 50 (3): 373–7. PMID 11839717.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.". J. Mol. Biol. 327 (1): 111–28. PMID 12614612.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Ramachandran N, Hainsworth E, Bhullar B, et al. (2004). "Self-assembling protein microarrays.". Science 305 (5680): 86–90. doi:10.1126/science.1097639. PMID 15232106.
Yu Z, Feng D, Liang C (2004). "Pairwise interactions of the six human MCM protein subunits.". J. Mol. Biol. 340 (5): 1197–206. doi:10.1016/j.jmb.2004.05.024. PMID 15236977.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.