Massachusetts Route 141
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| Route 141 |
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| West end: |  Route 10 in Easthampton |
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| Major junctions: |
 I-91 in Holyoke I-391 in Chicopee |
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| East end: |  US 20 in Springfield |
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Route 141 is a west-east state highway in the U.S. state of Massachusetts. Its western terminus is at Route 10 in Easthampton. Its eastern terminus is at U.S. Route 20 in Springfield while multiplexed with Route 21.
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