MARK4

From Wikipedia, the free encyclopedia

MAP/microtubule affinity-regulating kinase 4

Identifiers

MARK4; FLJ90097; KIAA1860; MARKL1; Nbla00650

External IDs

OMIM: 606495 MGI: 1920955 HomoloGene: 57146

Gene ontology
Molecular Function:	• nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • protein-tyrosine kinase activity • protein binding • ATP binding • microtubule binding • transferase activity • gamma-tubulin binding • ubiquitin binding • tau-protein kinase activity
Cellular Component:	• centrosome • neuron projection
Biological Process:	• microtubule bundle formation • protein amino acid phosphorylation • nervous system development • positive regulation of programmed cell death

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_031417 (mRNA)
NP_113605 (protein)

NM_172279 (mRNA)
NP_758483 (protein)

Location

Chr 19: 50.45 - 50.5 Mb

Chr 7: 18.58 - 18.62 Mb

Pubmed search

[1]

[2]

MAP/microtubule affinity-regulating kinase 4, also known as MARK4, is a human gene.^[1]

[edit] References

^ Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4.

[edit] Further reading

Drewes G, Ebneth A, Preuss U, et al. (1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.". Cell 89 (2): 297–308. PMID 9108484.
Kato T, Satoh S, Okabe H, et al. (2001). "Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis.". Neoplasia 3 (1): 4–9. doi:10.1038/sj/neo/7900132. PMID 11326310.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. PMID 11347906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Beghini A, Magnani I, Roversi G, et al. (2003). "The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines.". Oncogene 22 (17): 2581–91. PMID 12735302.
Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schneider A, Laage R, von Ahsen O, et al. (2004). "Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4.". J. Neurochem. 88 (5): 1114–26. PMID 15009667.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.