MARK3

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MAP/microtubule affinity-regulating kinase 3
PDB rendering based on 1ul7.
Available structures: 1ul7
Identifiers
Symbol(s) MARK3; CTAK1; KP78; PAR1A
External IDs OMIM: 602678 MGI: 1341865 HomoloGene: 55653
Orthologs
Human Mouse
Entrez 4140 17169
Ensembl ENSG00000075413 ENSMUSG00000007411
Uniprot P27448 Q91Y96
Refseq NM_002376 (mRNA)
NP_002367 (protein)		 XM_992051 (mRNA)
XP_997145 (protein)
Location Chr 14: 102.92 - 103.04 Mb Chr 12: 112.02 - 112.1 Mb
Pubmed search [1] [2]

MAP/microtubule affinity-regulating kinase 3, also known as MARK3, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: MARK3 MAP/microtubule affinity-regulating kinase 3.

[edit] Further reading

  • Tassan JP, Le Goff X (2004). "An overview of the KIN1/PAR-1/MARK kinase family.". Biol. Cell 96 (3): 193-9. doi:10.1016/j.biolcel.2003.10.009. PMID 15182702. 
  • Meller N, Liu YC, Collins TL, et al. (1996). "Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function.". Mol. Cell. Biol. 16 (10): 5782-91. PMID 8816492. 
  • Ono T, Kawabe T, Sonta S, Okamoto T (1998). "Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization.". Cytogenet. Cell Genet. 79 (1-2): 101-2. PMID 9533022. 
  • Peng CY, Graves PR, Ogg S, et al. (1998). "C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.". Cell Growth Differ. 9 (3): 197-208. PMID 9543386. 
  • Sun TQ, Lu B, Feng JJ, et al. (2001). "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.". Nat. Cell Biol. 3 (7): 628-36. doi:10.1038/35083016. PMID 11433294. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Spicer J, Rayter S, Young N, et al. (2003). "Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.". Oncogene 22 (30): 4752-6. doi:10.1038/sj.onc.1206669. PMID 12879020. 
  • Müller J, Ritt DA, Copeland TD, Morrison DK (2003). "Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.". EMBO J. 22 (17): 4431-42. doi:10.1093/emboj/cdg426. PMID 12941695. 
  • Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.". J. Biol. Chem. 279 (7): 5915-23. doi:10.1074/jbc.M304528200. PMID 14594945. 
  • Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339-46. doi:10.1002/pmic.200300528. PMID 14760703. 
  • Bachmann M, Hennemann H, Xing PX, et al. (2005). "The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint.". J. Biol. Chem. 279 (46): 48319-28. doi:10.1074/jbc.M404440200. PMID 15319445. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785-95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Göransson O, Deak M, Wullschleger S, et al. (2007). "Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.". J. Cell. Sci. 119 (Pt 19): 4059-70. doi:10.1242/jcs.03097. PMID 16968750. 
  • Dequiedt F, Martin M, Von Blume J, et al. (2006). "New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.". Mol. Cell. Biol. 26 (19): 7086-102. doi:10.1128/MCB.00231-06. PMID 16980613. 
  • Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537-47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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