MARK2

From Wikipedia, the free encyclopedia

MAP/microtubule affinity-regulating kinase 2

PDB rendering based on 1y8g.

Available structures: 1y8g, 1zmu, 1zmv, 1zmw

Identifiers

Symbol(s)

MARK2; EMK1; MGC99619; PAR-1

External IDs

OMIM: 600526 MGI: 99638 HomoloGene: 69013

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein binding • ATP binding • kinase activity • transferase activity
Cellular Component:	• nucleus • microtubule cytoskeleton • membrane • basal cortex
Biological Process:	• protein amino acid phosphorylation • protein kinase cascade • multicellular organismal development • cell differentiation • establishment and/or maintenance of epithelial cell polarity

Orthologs

Human

Mouse

Refseq

NM_001039468 (mRNA)
NP_001034557 (protein)

NM_001080388 (mRNA)
NP_001073857 (protein)

Location

Chr 11: 63.36 - 63.43 Mb

Chr 19: 7.34 - 7.36 Mb

Pubmed search

[1]

[2]

MAP/microtubule affinity-regulating kinase 2, also known as MARK2, is a human gene.^[1]

EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.^[1]

[edit] References

^ ^a ^b Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2.

[edit] Further reading

Courseaux A, Fernandes M, Grosgeorge J, et al. (1995). "Human EMK1 is located on 11q12-q13, close to COX8 and FTH1.". Mamm. Genome 6 (4): 311–2. PMID 7613050.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Courseaux A, Grosgeorge J, Gaudray P, et al. (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1).". Genomics 37 (3): 354–65. PMID 8938448.
Drewes G, Ebneth A, Preuss U, et al. (1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.". Cell 89 (2): 297–308. PMID 9108484.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Espinosa L, Navarro E (1998). "Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing.". Cytogenet. Cell Genet. 81 (3-4): 278–82. PMID 9730619.
Navarro E (1999). "Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search.". Cytogenet. Cell Genet. 86 (1): 66–7. PMID 10516437.
Sun TQ, Lu B, Feng JJ, et al. (2001). "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.". Nat. Cell Biol. 3 (7): 628–36. doi:10.1038/35083016. PMID 11433294.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMID 14976552.
Hueso M, Beltran V, Moreso F, et al. (2004). "Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients.". Biochim. Biophys. Acta 1689 (1): 58–65. doi:10.1016/j.bbadis.2004.01.008. PMID 15158914.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Suzuki A, Hirata M, Kamimura K, et al. (2004). "aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.". Curr. Biol. 14 (16): 1425–35. doi:10.1016/j.cub.2004.08.021. PMID 15324659.
Cohen D, Rodriguez-Boulan E, Müsch A (2004). "Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells.". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13792–7. doi:10.1073/pnas.0403684101. PMID 15365179.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hazarika P, McCarty MF, Prieto VG, et al. (2004). "Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1.". Cancer Res. 64 (20): 7361–9. doi:10.1158/0008-5472.CAN-04-0823. PMID 15492257.