MARCO

From Wikipedia, the free encyclopedia

Macrophage receptor with collagenous structure

Identifiers

MARCO; SCARA2

External IDs

OMIM: 604870 MGI: 1309998 HomoloGene: 4928

Gene ontology
Molecular Function:	• scavenger receptor activity • pattern recognition receptor activity
Cellular Component:	• cytoplasm • integral to plasma membrane • membrane
Biological Process:	• phosphate transport • cell surface receptor linked signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006770 (mRNA)
NP_006761 (protein)

NM_010766 (mRNA)
NP_034896 (protein)

Location

Chr 2: 119.42 - 119.47 Mb

Chr 1: 122.3 - 122.33 Mb

Pubmed search

[1]

[2]

Macrophage receptor with collagenous structure, also known as MARCO, is a human gene.^[1]

The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.^[1]

[edit] References

^ ^a ^b Entrez Gene: MARCO macrophage receptor with collagenous structure.

[edit] Further reading

Elomaa O, Kangas M, Sahlberg C, et al. (1995). "Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages.". Cell 80 (4): 603–9. PMID 7867067.
Elomaa O, Sankala M, Pikkarainen T, et al. (1998). "Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region.". J. Biol. Chem. 273 (8): 4530–8. PMID 9468508.
Kangas M, Brännström A, Elomaa O, et al. (1999). "Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor.". Genomics 58 (1): 82–9. doi:10.1006/geno.1999.5811. PMID 10331948.
Elshourbagy NA, Li X, Terrett J, et al. (2000). "Molecular characterization of a human scavenger receptor, human MARCO.". Eur. J. Biochem. 267 (3): 919–26. PMID 10651831.
Seta N, Granfors K, Sahly H, et al. (2001). "Expression of host defense scavenger receptors in spondylarthropathy.". Arthritis Rheum. 44 (4): 931–9. doi:10.1002/1529-0131(200104)44:4<931::AID-ANR150>3.0.CO;2-T. PMID 11315932.
Brännström A, Sankala M, Tryggvason K, Pikkarainen T (2002). "Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO.". Biochem. Biophys. Res. Commun. 290 (5): 1462–9. doi:10.1006/bbrc.2002.6378. PMID 11820786.
Sankala M, Brännström A, Schulthess T, et al. (2002). "Characterization of recombinant soluble macrophage scavenger receptor MARCO.". J. Biol. Chem. 277 (36): 33378–85. doi:10.1074/jbc.M204494200. PMID 12097327.
Mirani M, Elenkov I, Volpi S, et al. (2002). "HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection.". J. Immunol. 169 (11): 6361–8. PMID 12444143.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bin LH, Nielson LD, Liu X, et al. (2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair.". J. Immunol. 171 (2): 924–30. PMID 12847263.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Arredouani MS, Palecanda A, Koziel H, et al. (2005). "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages.". J. Immunol. 175 (9): 6058–64. PMID 16237101.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.