Talk:MAPK/ERK pathway
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[edit] Disease?
Nice work, John! It would be good to summarise the involvement of various components of the pathway in human disease in the article. Cancer is the obvious one of course, but there are others. There is accumulating evidence for the role of the ERK cascade in neurodegeneration, for example (eg. Entrez PubMed 15247297). Your drawing style is very clear. I think it would be nice if we agreed on a common way of illustrating protein domains. For describing something like PKC signaling it would indispensable. Peter Z.Talk 18:49, 19 June 2006 (UTC)
- Thanks for the pointer to that article. My personal interest in this pathway is centered on links to it from estrogen receptors and the possible relevance of those links to adult brain function. I agree that we should strive for standardization. --JWSchmidt 23:30, 19 June 2006 (UTC)
[edit] ERK and MAPK
I am not an expert on MAPK/ERK signalling, but as far as I know is p42/44 MAPK = ERK(1/2), however p38 MAPK is NOT referred to as an ERK. "MAPKs can be divided into three main subgroups: extracellular responsive kinases (ERK or p42/44MAPK), p38MAPK and c-Jun N-terminal kinases (JNK)" Citat from Johnson and Lapadat, 2002 G.L. Johnson and R. Lapadat, Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases, Science 298 (2002), pp. 1911–1912. 130.226.29.13 11:36, 26 July 2007 (UTC)
