MAPKAP1

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase associated protein 1

Identifiers

MAPKAP1; MIP1; MGC2745; SIN1; SIN1b; SIN1g

External IDs

OMIM: 610558 MGI: 2444554 HomoloGene: 11473

Gene ontology
Molecular Function:	• kinase activity • Ras GTPase binding
Cellular Component:	• cellular_component
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001006617 (mRNA)
NP_001006618 (protein)

NM_177345 (mRNA)
NP_796319 (protein)

Location

Chr 9: 127.24 - 127.51 Mb

Chr 2: 34.23 - 34.45 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase associated protein 1, also known as MAPKAP1, is a human gene.^[1]

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1.

[edit] Further reading

Colicelli J, Nicolette C, Birchmeier C, et al. (1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2913-7. PMID 1849280.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Schroder W, Cloonan N, Bushell G, Sculley T (2004). "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene.". Gene 339: 17-23. doi:10.1016/j.gene.2004.07.001. PMID 15363842.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Schroder W, Bushell G, Sculley T (2005). "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins.". Cell. Signal. 17 (6): 761-7. doi:10.1016/j.cellsig.2004.10.015. PMID 15722200.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785-95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Cheng J, Zhang D, Kim K, et al. (2005). "Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.". Mol. Cell. Biol. 25 (14): 5955-64. doi:10.1128/MCB.25.14.5955-5964.2005. PMID 15988011.
Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon.". Hum. Mol. Genet. 14 (16): 2289-303. doi:10.1093/hmg/ddi233. PMID 16000324.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Frias MA, Thoreen CC, Jaffe JD, et al. (2006). "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.". Curr. Biol. 16 (18): 1865-70. doi:10.1016/j.cub.2006.08.001. PMID 16919458.
Jacinto E, Facchinetti V, Liu D, et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.". Cell 127 (1): 125-37. doi:10.1016/j.cell.2006.08.033. PMID 16962653.
Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.". Genes Dev. 20 (20): 2820-32. doi:10.1101/gad.1461206. PMID 17043309.
Makino C, Sano Y, Shinagawa T, et al. (2007). "Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway.". Genes Cells 11 (11): 1239-51. doi:10.1111/j.1365-2443.2006.01016.x. PMID 17054722.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Schroder WA, Buck M, Cloonan N, et al. (2007). "Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling.". Cell. Signal. 19 (6): 1279-89. doi:10.1016/j.cellsig.2007.01.013. PMID 17303383.