MAP3K14

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase kinase kinase 14

Identifiers

MAP3K14; FTDCR1B; HS; HSNIK; NIK

External IDs

OMIM: 604655 MGI: 1858204 HomoloGene: 2940

Gene ontology
Molecular Function:	• nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003954 (mRNA)
NP_003945 (protein)

NM_016896 (mRNA)
NP_058592 (protein)

Location

Chr 17: 40.7 - 40.75 Mb

Chr 11: 103.04 - 103.08 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase kinase kinase 14, also known as MAP3K14, is a human gene.^[1]

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14.

[edit] Further reading

Malinin NL, Boldin MP, Kovalenko AV, Wallach D (1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.". Nature 385 (6616): 540–4. doi:10.1038/385540a0. PMID 9020361.
Régnier CH, Song HY, Gao X, et al. (1997). "Identification and characterization of an IkappaB kinase.". Cell 90 (2): 373–83. PMID 9244310.
Song HY, Régnier CH, Kirschning CJ, et al. (1997). "Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792–6. PMID 9275204.
Woronicz JD, Gao X, Cao Z, et al. (1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.". Science 278 (5339): 866–9. PMID 9346485.
Ling L, Cao Z, Goeddel DV (1998). "NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3792–7. PMID 9520446.
Lee FS, Peters RT, Dang LC, Maniatis T (1998). "MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9319–24. PMID 9689078.
Lin X, Mu Y, Cunningham ET, et al. (1998). "Molecular determinants of NF-kappaB-inducing kinase action.". Mol. Cell. Biol. 18 (10): 5899–907. PMID 9742107.
Cohen L, Henzel WJ, Baeuerle PA (1998). "IKAP is a scaffold protein of the IkappaB kinase complex.". Nature 395 (6699): 292–6. doi:10.1038/26254. PMID 9751059.
Aronsson FC, Magnusson P, Andersson B, et al. (1998). "The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.". Hum. Genet. 103 (3): 340–5. PMID 9799091.
Nemoto S, DiDonato JA, Lin A (1998). "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.". Mol. Cell. Biol. 18 (12): 7336–43. PMID 9819420.
Li Y, Kang J, Friedman J, et al. (1999). "Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 1042–7. PMID 9927690.
Lallena MJ, Diaz-Meco MT, Bren G, et al. (1999). "Activation of IkappaB kinase beta by protein kinase C isoforms.". Mol. Cell. Biol. 19 (3): 2180–8. PMID 10022904.
Lin X, Cunningham ET, Mu Y, et al. (1999). "The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases.". Immunity 10 (2): 271–80. PMID 10072079.
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, et al. (1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.". Nature 398 (6724): 252–6. doi:10.1038/18465. PMID 10094049.
Delhase M, Hayakawa M, Chen Y, Karin M (1999). "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.". Science 284 (5412): 309–13. PMID 10195894.
Hu WH, Johnson H, Shu HB (1999). "Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways.". J. Biol. Chem. 274 (43): 30603–10. PMID 10521444.
Yamamoto Y, Yin MJ, Gaynor RB (2000). "IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.". Mol. Cell. Biol. 20 (10): 3655–66. PMID 10779355.
Xiao G, Sun SC (2000). "Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain.". J. Biol. Chem. 275 (28): 21081–5. doi:10.1074/jbc.M002552200. PMID 10887201.
Chaudhary PM, Eby MT, Jasmin A, et al. (2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs.". Oncogene 19 (39): 4451–60. doi:10.1038/sj.onc.1203812. PMID 11002417.
Kumar A, Eby MT, Sinha S, et al. (2001). "The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.". J. Biol. Chem. 276 (4): 2668–77. doi:10.1074/jbc.M008356200. PMID 11035039.