MAP2

From Wikipedia, the free encyclopedia

Microtubule-associated protein 2

Identifiers

MAP2; DKFZp686I2148; MAP2A; MAP2B; MAP2C

External IDs

OMIM: 157130 MGI: 97175 HomoloGene: 1779

Gene ontology
Molecular Function:	• molecular_function • structural molecule activity • calmodulin binding
Cellular Component:	• cytoskeleton • microtubule • microtubule associated complex
Biological Process:	• negative regulation of microtubule depolymerization • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001039538 (mRNA)
NP_001034627 (protein)

XM_001001964 (mRNA)
XP_001001964 (protein)

Location

Chr 2: 210 - 210.3 Mb

Chr 1: 66.18 - 66.38 Mb

Pubmed search

[1]

[2]

Microtubule-associated protein 2, also known as MAP2, is a human gene.

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. MAP2 serves to stabilize microtubules (MT) growth by crosslinking MT with intermediate filaments and other MT. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described.^[1]

[edit] References

^ Entrez Gene: MAP2 microtubule-associated protein 2.

[edit] Further reading

Roses AD, Einstein G, Gilbert J, et al. (1996). "Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism.". Ann. N. Y. Acad. Sci. 777: 146–57. PMID 8624078.
Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease.". Folia Biol. (Praha) 42 (5): 227–30. PMID 8997639.
Shafit-Zagardo B, Kalcheva N (1999). "Making sense of the multiple MAP-2 transcripts and their role in the neuron.". Mol. Neurobiol. 16 (2): 149–62. PMID 9588626.
Liu Y, Saad RS, Shen SS, Silverman JF (2003). "Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.". Advances in anatomic pathology 10 (2): 101–6. PMID 12605092.
Ainsztein AM, Purich DL (1992). "Cleavage of bovine brain microtubule-associated protein-2 by human immunodeficiency virus proteinase.". J. Neurochem. 59 (3): 874–80. PMID 1494913.
Alberts MJ, Kandt RS, Pericak-Vance MA, et al. (1991). "MspI RFLP for microtubule associated protein-2 (MAP2).". Nucleic Acids Res. 19 (4): 960. PMID 1708129.
Wallin M, Deinum J, Goobar L, Danielson UH (1990). "Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases.". J. Gen. Virol. 71 ( Pt 9): 1985–91. PMID 2212989.
Kosik KS, Orecchio LD, Bakalis S, et al. (1988). "Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles.". J. Neurochem. 51 (2): 587–98. PMID 2455776.
Dammerman M, Yen SH, Shafit-Zagardo B (1990). "Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles.". J. Neurosci. Res. 24 (4): 487–95. doi:10.1002/jnr.490240405. PMID 2481044.
Obar RA, Dingus J, Bayley H, Vallee RB (1990). "The RII subunit of cAMP-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A, 2B, and 2C.". Neuron 3 (5): 639–45. PMID 2561973.
Rubino HM, Dammerman M, Shafit-Zagardo B, Erlichman J (1990). "Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2.". Neuron 3 (5): 631–8. PMID 2701845.
Herrmann H, Wiche G (1987). "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin.". J. Biol. Chem. 262 (3): 1320–5. PMID 3027087.
Neve RL, Harris P, Kosik KS, et al. (1987). "Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2.". Brain Res. 387 (3): 271–80. PMID 3103857.
Garner CC, Tucker RP, Matus A (1989). "Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites.". Nature 336 (6200): 674–7. doi:10.1038/336674a0. PMID 3200318.
Kalcheva N, Albala J, O'Guin K, et al. (1995). "Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms.". Proc. Natl. Acad. Sci. U.S.A. 92 (24): 10894–8. PMID 7479905.
Takahashi M, Tomizawa K, Sato K, et al. (1995). "A novel tau-tubulin kinase from bovine brain.". FEBS Lett. 372 (1): 59–64. PMID 7556643.
Kindler S, Garner CC (1995). "Four repeat MAP2 isoforms in human and rat brain.". Brain Res. Mol. Brain Res. 26 (1-2): 218–24. PMID 7854050.
Albala JS, Kalcheva N, Shafit-Zagardo B (1994). "Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2).". Gene 136 (1-2): 377–8. PMID 8294038.
Illenberger S, Drewes G, Trinczek B, et al. (1996). "Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.". J. Biol. Chem. 271 (18): 10834–43. PMID 8631898.