MAP1B

From Wikipedia, the free encyclopedia

Microtubule-associated protein 1B

Identifiers

MAP1B; DKFZp686E1099; DKFZp686F1345; FLJ38954; FUTSCH; MAP5

External IDs

OMIM: 157129 MGI: 1306778 HomoloGene: 38111

Gene ontology
Molecular Function:	• structural molecule activity • protein binding
Cellular Component:	• microtubule • microtubule associated complex
Biological Process:	• microtubule bundle formation • dendrite development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005909 (mRNA)
NP_005900 (protein)

NM_008634 (mRNA)
NP_032660 (protein)

Location

Chr 5: 71.44 - 71.54 Mb

Chr 13: 100.52 - 100.62 Mb

Pubmed search

[1]

[2]

Microtubule-associated protein 1B, also known as MAP1B, is a human gene.^[1]

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAP1B microtubule-associated protein 1B.

[edit] Further reading

Hammarback JA, Obar RA, Hughes SM, Vallee RB (1991). "MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain.". Neuron 7 (1): 129-39. PMID 1712602.
Lien LL, Boyce FM, Kleyn P, et al. (1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13.". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873-6. PMID 1881920.
Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS.". J. Neurosci. 9 (5): 1712-30. PMID 2470876.
Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J (1994). "Role of phosphorylated MAPlB in neuritogenesis.". Cell Biol. Int. 18 (5): 309-14. PMID 7519512.
Lien LL, Feener CA, Fischbach N, Kunkel LM (1995). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15.". Genomics 22 (2): 273-80. doi:10.1006/geno.1994.1384. PMID 7806212.
Ohyu J, Takashima S (1998). "Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions.". Brain Dev. 20 (1): 22-6. PMID 9533556.
Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC (1998). "Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium.". J. Cell. Sci. 111 ( Pt 10): 1351-61. PMID 9570753.
Tögel M, Wiche G, Propst F (1998). "Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain.". J. Cell Biol. 143 (3): 695-707. PMID 9813091.
Hanley JG, Koulen P, Bedford F, et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses.". Nature 397 (6714): 66-9. doi:10.1038/16258. PMID 9892354.
Jensen PH, Islam K, Kenney J, et al. (2000). "Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments.". J. Biol. Chem. 275 (28): 21500-7. doi:10.1074/jbc.M000099200. PMID 10764738.
Tanner SL, Franzen R, Jaffe H, Quarles RH (2000). "Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein.". J. Neurochem. 75 (2): 553-62. PMID 10899930.
Mei X, Sweatt AJ, Hammarback JA (2000). "Regulation of microtubule-associated protein 1B (MAP1B) subunit composition.". J. Neurosci. Res. 62 (1): 56-64. PMID 11002287.
Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B.". J. Neurosci. 20 (23): 8643-50. PMID 11102469.
Franzen R, Tanner SL, Dashiell SM, et al. (2002). "Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein.". J. Cell Biol. 155 (6): 893-8. doi:10.1083/jcb.200108137. PMID 11733546.
Ding J, Liu JJ, Kowal AS, et al. (2002). "Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin.". J. Cell Biol. 158 (3): 427-33. doi:10.1083/jcb.200202055. PMID 12147674.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA (2004). "Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region.". Biomol. Eng. 20 (3): 91-6. PMID 12684070.
Chang L, Jones Y, Ellisman MH, et al. (2003). "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.". Dev. Cell 4 (4): 521-33. PMID 12689591.
Opal P, Garcia JJ, Propst F, et al. (2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis.". J. Biol. Chem. 278 (36): 34691-9. doi:10.1074/jbc.M302785200. PMID 12807913.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.