Talk:Mannitol
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[edit] Mannitol in Plants
Can someone (eg. a botanist) write something about mannitol in plants: mannitol dehydrogenase (MDH), it being produced by olives, its relevance in abiotic stress. THANKS massa 14:30, 26 February 2006 (UTC)
[edit] Permeability
Earlier in the article it mentions being able to open the blood-brin barrier, but later on it says it is not able to cross biological membranes - is this an inconsistency, or does the blood-brain barrier not count as a membrane? --CharlesC 08:23, 13 July 2006 (UTC)
Or does it just "open" the blood-brain barrier without actually passing it? Sweetman 07:00, 8 August 2006 (UTC)
- Here's what the article states and if you read it slowly and carefully, I feel you might just see what the author was stating. In the presence of all that other info, I see how the meaning is easily lost. Here:
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- Mannitol can also be used to open the blood-brain barrier by temporarily shrinking the tightly coupled endothelial cells that make up the barrier. This makes mannitol indispensable for delivering various drugs directly to the brain (e.g. in the treatment of Alzheimer's disease).
- See? The Mannitol opens the barrier via the shrinkage allowing the other agents to passs through. Once the endothelial cells are free of the shrinking effect, they swell back to normal size. The mannitol is the agent that allows this but isn't the agent that is needed to pass thru. Hope that helps. Of course, I see now your question was back in August. Here's hoping you have this article marked on your watch page! Lisapollison 10:22, 11 December 2006 (UTC)
[edit] Scar Tissue Mention
Mannitol is mentioned in Anthony Kiedis' book Scar Tissue. He states he use to watch his dad mix the laxitive Mannitol to cocaine to make it more profitable. -- MH 11 jan 07 —The preceding unsigned comment was added by 131.137.245.198 (talk) 13:49, 11 January 2007 (UTC).
[edit] Sugar?
Does mannitol count as a sugar, even though it isn't a carbohydrate? Mauvila 20:02, 8 February 2007 (UTC)
- Why isn't it a carbohydrate? Polyols or sugar alcohols are carbohydrates, i guess. —The preceding unsigned comment was added by 196.205.224.53 (talk) 16:16, 10 February 2007 (UTC).
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- I'm not sure...I define carbohydrates as how they originally were named, that is chemicals that have an empirical chemical formula of CH2O [C-(carbo-), H20 (hydr-)]. Mannitol is a reduced mannose, so it no longer adheres to the 1 C, 2 H, 1 O ratio of atoms. Mauvila 07:38, 14 April 2007 (UTC)
[edit] isolated from manna?
so, i am confused if manna is actually a substance that exists; could someone be more specific, rather than a citation from 1880? —Preceding unsigned comment added by 68.222.197.74 (talk) 14:48, 7 October 2007 (UTC)
- Ah sorry, at the time I added the reference the Manna page had a section since removed. Yes, the substance referred to does exist - the "Manna#Modern term" section used to say:
- The term manna is also used in the modern context to refer to a secretion from various plants, including certain desert or semi-desert shrubs and especially the Ash Fraxinus ornus (manna or flowering ash) of Southern Europe. The material is produced by sap-sucking insects that secrete a honeydew like liquid, that when dried forms manna; it has a sweet taste. Eaten in large quantities, it is mildly laxative and has been used medicinally for that purpose.
- It seems to have gone through some edit-warring since then, but I'll try and work out when and why that section was removed, and hopefully work out from that how to update the reference here to be useful. Hv 22:04, 9 October 2007 (UTC)
- Ok, I've updated that paragraph - the explicit reference in Manna has moved to the section "#Later cultural references", and is no longer sufficiently clear and isolated to warrant linking directly, so I redrafted to try and ensure the relevant information is in. Hv 22:15, 9 October 2007 (UTC)
[edit] drug basics/general information
Every drug indexed in wikipedia should contain at minimum (or be edited to have) the following information: Drug class, FDA approved indication/ also other uses, mechanism of action, contraindication, side effects/ adverse reactions, interactions with other drugs, route of administration/ and dosage, pregnancy category, percautions, brand names, how it's supplied and drug company, approximate cost.
Dr. ATL MD
