Mannotetraose 2-alpha-N-acetylglucosaminyltransferase
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In enzymology, a mannotetraose 2-alpha-N-acetylglucosaminyltransferase (EC 2.4.1.138) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-D-glucosamine + 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D- mannose
UDP + 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D- mannosyl)-1,2-alpha-D-mannosyl-D-mannose
The 3 substrates of this enzyme are UDP-N-acetyl-D-glucosamine, 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-, and mannose, whereas its 3 products are UDP, 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-, and mannosyl)-1,2-alpha-D-mannosyl-D-mannose.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase. Other names in common use include alpha-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine mannoside, and alpha1->2-alphacetylglucosaminyltransferase.
[edit] References
- IUBMB entry for 2.4.1.138
- BRENDA references for 2.4.1.138 (Recommended.)
- PubMed references for 2.4.1.138
- PubMed Central references for 2.4.1.138
- Google Scholar references for 2.4.1.138
- Douglas RH, Ballou CE (1982). "Purification of an alpha-N-acetylglucosaminyltransferase from the yeast Kluyveromyces lactis and a study of mutants defective in this enzyme activity". Biochemistry. 21: 1561–70. doi:. PMID 6211189.
[edit] External links
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- The CAS registry number for this enzyme class is 81032-47-5.
[edit] Gene Ontology (GO) codes
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