Mannose-6-phosphate
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| Mannose-6-phosphate | |
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| Identifiers | |
| CAS number | [3672-15-9] |
| PubChem | |
| MeSH | |
| SMILES | C(C1C(C(C(C(O1)O)O)O)O)OP(=O)(O)O |
| Properties | |
| Molecular formula | C6H13O9P |
| Molar mass | 260.136 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Mannose-6-phosphate (M6P) is a molecule bound by lectin in the immune system. M6P is converted to fructose 6-phosphate by mannose phosphate isomerase.
M6P is a targeting signal for acid hydrolase precursor proteins that are destined for transport to lysosomes. The M6P tag is added to such proteins in the cis-Golgi apparatus. Specifically, in a reaction involving uridine diphosphate (UDP) and N-acetylglucosamine, the enzyme UDP-N-acetylglucosamine:N-acetylglucosaminyl-1-phosphotransferase catalyzes the N-linked glycosylation of asparagine residues with M6P. Once appropriately marked with the M6P targeting signal, these proteins are moved to the trans-Golgi. There, the M6P moiety is recognized by mannose 6-phosphate receptor (MPR) proteins.
The MPRs traffic in vesicles to the lysosome via an endosome.
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