MAN2A1

From Wikipedia, the free encyclopedia

Mannosidase, alpha, class 2A, member 1

Identifiers

MAN2A1; MANA2; MANII

External IDs

OMIM: 154582 MGI: 104669 HomoloGene: 1777

Gene ontology
Molecular Function:	• alpha-mannosidase activity • mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity • mannosidase activity • hydrolase activity, acting on glycosyl bonds
Cellular Component:	• Golgi membrane • membrane fraction • Golgi apparatus • membrane • integral to membrane
Biological Process:	• carbohydrate metabolic process • mannose metabolic process • metabolic process • glycoprotein biosynthetic process

Orthologs

Human

Mouse

Refseq

NM_002372 (mRNA)
NP_002363 (protein)

NM_008549 (mRNA)
NP_032575 (protein)

Location

Chr 5: 109.05 - 109.23 Mb

Chr 17: 64.5 - 64.65 Mb

Pubmed search

[1]

[2]

Mannosidase, alpha, class 2A, member 1, also known as MAN2A1, is a human gene.^[1]

This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1.

[edit] Further reading

Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.". Biochimie 83 (8): 783–90. PMID 11530211.
Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.". Virology 187 (1): 377–82. PMID 1736542.
Moremen KW, Robbins PW (1992). "Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans.". J. Cell Biol. 115 (6): 1521–34. PMID 1757461.
Moremen KW, Touster O, Robbins PW (1991). "Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme.". J. Biol. Chem. 266 (25): 16876–85. PMID 1885615.
Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.". AIDS Res. Hum. Retroviruses 6 (3): 371–80. PMID 2187500.
Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. PMID 2283726.
Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.". J. Biol. Chem. 265 (18): 10373–82. PMID 2355006.
Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. PMID 2541446.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.". J. Virol. 63 (6): 2452–6. PMID 2542563.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.". AIDS Res. Hum. Retroviruses 3 (3): 265–82. PMID 2829950.
Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.". Biochem. Biophys. Res. Commun. 141 (1): 33–8. PMID 3099781.
Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. PMID 3264072.
Moremen KW, Touster O (1985). "Biosynthesis and modification of Golgi mannosidase II in HeLa and 3T3 cells.". J. Biol. Chem. 260 (11): 6654–62. PMID 3922977.
Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.". J. Virol. 67 (1): 150–60. PMID 8093218.
Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.". Biochemistry 32 (41): 11087–99. PMID 8218172.
Velasco A, Hendricks L, Moremen KW, et al. (1993). "Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II.". J. Cell Biol. 122 (1): 39–51. PMID 8314846.
Misago M, Liao YF, Kudo S, et al. (1996). "Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11766–70. PMID 8524845.
Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. PMID 8673525.
Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.". J. Virol. 70 (11): 7462–70. PMID 8892864.