Talk:Malignant fibrous histiocytoma

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The histopathologic diagnosis of malignant fibrous histiocytoma is controversial, as there is no cell called the "fibrous histocyte". Probably a more accurate morphologic diagnosis is anaplastic soft tissue sarcoma with multinucleated cells.

The entity malignant fibrous histiocytoma in rodent toxicology is entirely different from the human tumour described here, it occurs predominantly at the site of repeated subcutaneous injections. Rodents have been shown to develop MFH at the sites of implantation of inert foreign materials and the sites of injection of a number of otherwise innocuous chemicals (e.g., glucose, fructose). (1) Haseman, J., J. Bourbina, and S. Eustis. 1994. Effect of individual housing and other experimental design factors on tumour incidence in B6C3F1 mice. Fundam. Appl. Toxicol. 23:44–52. (2) Berenblum, I. 1974. Carcinogenesis as a biological problem. Amsterdam: North Holland Publishing. (3) Grasso, P., and L. Golberg. 1967. Subcutaneous sarcoma as an index of carcinogenic potency. Food Cosmet. Toxicol. 4:297–320. Farmacol (talk) 13:35, 13 February 2008 (UTC)