Maleylacetoacetate isomerase

From Wikipedia, the free encyclopedia

In enzymology, a maleylacetoacetate isomerase (EC 5.2.1.2) is an enzyme that catalyzes the chemical reaction

4-maleylacetoacetate 4-fumarylacetoacetate

Hence, this enzyme has one substrate, 4-maleylacetoacetate, and one product, 4-fumarylacetoacetate.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 4-maleylacetoacetate cis-trans-isomerase. Other names in common use include maleylacetoacetic isomerase, maleylacetone isomerase, and maleylacetone cis-trans-isomerase. This enzyme participates in tyrosine metabolism and styrene degradation.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1FW1, 2CZ2, and 2CZ3.

[edit] References

• IUBMB entry for 5.2.1.2
• BRENDA references for 5.2.1.2 (Recommended.)
• PubMed references for 5.2.1.2
• PubMed Central references for 5.2.1.2
• Google Scholar references for 5.2.1.2
• EDWARDS SW, KNOX WE (1956). "Homogentisate metabolism: the isomerization of maleylacetoacetate by an enzyme which requires glutathione". J. Biol. Chem. 220: 79–91. PMID 13319328. 
• Lack L (1961). "Enzymic cis-trans isomerization of maleylpyruvic acid". J. Biol. Chem. 236: 2835–2840. 
• Seltzer S (1973). "Purification and properties of maleylacetone cis-trans isomerase from vibrio 01". J. Biol. Chem. 248: 215–22. PMID 4692831. 

[edit] External links

The CAS registry number for this enzyme class is 9023-75-0.

• IUBMB entry for 5.2.1.2

• KEGG entry for 5.2.1.2

• BRENDA entry for 5.2.1.2

• NiceZyme view of 5.2.1.2

• EC2PDB: PDB structures for 5.2.1.2

• PRIAM entry for 5.2.1.2

• PUMA2 entry for 5.2.1.2

• IntEnz: Integrated Enzyme entry for 5.2.1.2

• MetaCyc entry for 5.2.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016034: maleylacetoacetate isomerase

• AMIGO entry for GO code 0016034: maleylacetoacetate isomerase