Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)

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In enzymology, a malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (EC 1.1.1.40) is an enzyme that catalyzes the chemical reaction

(S)-malate + NADP⁺ $\rightleftharpoons$ pyruvate + CO₂ + NADPH

Thus, the two substrates of this enzyme are (S)-malate and NADP⁺, whereas its 3 products are pyruvate, CO₂, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating). Other names in common use include 'malic' enzyme, pyruvic-malic carboxylase, malate dehydrogenase (decarboxylating, NADP+), NADP+-linked decarboxylating malic enzyme, NADP+-malic enzyme, NADP+-specific malic enzyme, NADP+-specific malate dehydrogenase, malate dehydrogenase (NADP+, decarboxylating), L-malate:NADP+ oxidoreductase, and malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+). This enzyme participates in pyruvate metabolism and carbon fixation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1GQ2, 1GZ4, and 2AW5.

[edit] References

IUBMB entry for 1.1.1.40
BRENDA references for 1.1.1.40 (Recommended.)
PubMed references for 1.1.1.40
PubMed Central references for 1.1.1.40
Google Scholar references for 1.1.1.40
HARARY I, KOREY SR, OCHOA S (1953). "Biosynthesis of dicarboxylic acids by carbon dioxide fixation. VII Equilibrium of malic enzyme reaction". J. Biol. Chem. 203: 595–604. PMID 13084629.
Ochoa S, Mehler AH and Kornberg A (1948). "Biosynthesis of dicarboxylic acids by carbon dioxide fixation. I Isolation and properties of an enzyme from pigeon liver catalyzing the reversible oxidative decarboxylation of l-malic acid". J. Biol. Chem. 174: 979–1000.
RUTTER WJ, LARDY HA (1958). "Purification and properties of pigeon liver malic enzyme". J. Biol. Chem. 233: 374–82. PMID 13563505.
Strickland RG (1959). "Some properties of the malic enzyme of pigeon liver. 1. Conversion of malate into pyruvate". Biochem. J. 73: 646–654.
Strickland RG (1959). "Some properties of the malic enzyme of pigeon liver. 2. Synthesis of malate from pyruvate". Biochem. J. 73: 654–659.
Walker DA (1960). "Physiological studies on acid metabolism. 7. Malic enzyme from Kalanchoe crenata: effects of carbon dioxide concentration". Biochem. J. 74: 216–223.