MALL

From Wikipedia, the free encyclopedia

Mal, T-cell differentiation protein-like

Identifiers

MALL; BENE; MGC4419

External IDs

OMIM: 602022 MGI: 2385152 HomoloGene: 3965

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• Golgi membrane • plasma membrane • integral to membrane • cytoplasmic membrane-bound vesicle • clathrin-coated vesicle • lipid raft
Biological Process:	• cholesterol homeostasis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005434 (mRNA)
NP_005425 (protein)

NM_145532 (mRNA)
NP_663507 (protein)

Location

Chr 2: 110.2 - 110.23 Mb

Chr 2: 127.4 - 127.42 Mb

Pubmed search

[1]

[2]

Mal, T-cell differentiation protein-like, also known as MALL, is a human gene.^[1]

This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1.^[1]

[edit] References

^ ^a ^b Entrez Gene: MALL mal, T-cell differentiation protein-like.

[edit] Further reading

Kurdina MI, Denisov LE (1993). "[An evaluation of the efficacy of dispensary care as a method for the active detection of skin melanoma]". Klinicheskaia meditsina 70 (11-12): 68-70. PMID 1294831.
Lautner-Rieske A, Thiebe R, Zachau HG (1995). "Searching for non-V kappa transcripts from the human immunoglobulin kappa locus.". Gene 159 (2): 199-202. PMID 7622049.
Magyar JP, Ebensperger C, Schaeren-Wiemers N, Suter U (1997). "Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are members of an extended gene family.". Gene 189 (2): 269-75. PMID 9168137.
Hildebrandt F, Otto E, Rensing C, et al. (1997). "A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1.". Nat. Genet. 17 (2): 149-53. doi:10.1038/ng1097-149. PMID 9326933.
Saunier S, Calado J, Heilig R, et al. (1998). "A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis.". Hum. Mol. Genet. 6 (13): 2317-23. PMID 9361039.
de Marco MC, Kremer L, Albar JP, et al. (2001). "BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells.". J. Biol. Chem. 276 (25): 23009-17. doi:10.1074/jbc.M009739200. PMID 11294831.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.