MAGOH

From Wikipedia, the free encyclopedia

Mago-nashi homolog, proliferation-associated (Drosophila)

PDB rendering based on 1hl6.

Available structures: 1hl6, 1oo0, 1p27, 1rk8, 2hyi, 2j0q, 2j0s

Identifiers

Symbol(s)

MAGOH;

External IDs

OMIM: 602603 MGI: 1330312 HomoloGene: 1776

Gene ontology
Molecular Function:	• RNA binding • protein binding
Cellular Component:	• nucleus • spliceosome
Biological Process:	• mRNA processing • transport • female gamete generation • RNA splicing • mRNA transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002370 (mRNA)
NP_002361 (protein)

NM_010760 (mRNA)
NP_034890 (protein)

Location

Chr 1: 53.47 - 53.48 Mb

n/a

Pubmed search

[1]

[2]

Mago-nashi homolog, proliferation-associated (Drosophila), also known as MAGOH, is a human gene.^[1]

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAGOH mago-nashi homolog, proliferation-associated (Drosophila).

[edit] Further reading

Newmark PA, Mohr SE, Gong L, Boswell RE (1997). "mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila.". Development 124 (16): 3197-207. PMID 9272960.
Zhao XF, Colaizzo-Anas T, Nowak NJ, et al. (1998). "The mammalian homologue of mago nashi encodes a serum-inducible protein.". Genomics 47 (2): 319-22. doi:10.1006/geno.1997.5126. PMID 9479507.
Zhao XF, Nowak NJ, Shows TB, Aplan PD (2000). "MAGOH interacts with a novel RNA-binding protein.". Genomics 63 (1): 145-8. doi:10.1006/geno.1999.6064. PMID 10662555.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Mingot JM, Kostka S, Kraft R, et al. (2001). "Importin 13: a novel mediator of nuclear import and export.". EMBO J. 20 (14): 3685-94. doi:10.1093/emboj/20.14.3685. PMID 11447110.
Hachet O, Ephrussi A (2002). "Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport.". Curr. Biol. 11 (21): 1666-74. PMID 11696323.
Kataoka N, Diem MD, Kim VN, et al. (2002). "Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.". EMBO J. 20 (22): 6424-33. doi:10.1093/emboj/20.22.6424. PMID 11707413.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426-39. PMID 11991638.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fribourg S, Gatfield D, Izaurralde E, Conti E (2003). "A novel mode of RBD-protein recognition in the Y14-Mago complex.". Nat. Struct. Biol. 10 (6): 433-9. doi:10.1038/nsb926. PMID 12730685.
Lau CK, Diem MD, Dreyfuss G, Van Duyne GD (2004). "Structure of the Y14-Magoh core of the exon junction complex.". Curr. Biol. 13 (11): 933-41. PMID 12781131.
Chan CC, Dostie J, Diem MD, et al. (2004). "eIF4A3 is a novel component of the exon junction complex.". RNA 10 (2): 200-9. PMID 14730019.
Palacios IM, Gatfield D, St Johnston D, Izaurralde E (2004). "An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay.". Nature 427 (6976): 753-7. doi:10.1038/nature02351. PMID 14973490.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ballut L, Marchadier B, Baguet A, et al. (2005). "The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.". Nat. Struct. Mol. Biol. 12 (10): 861-9. doi:10.1038/nsmb990. PMID 16170325.
Gehring NH, Kunz JB, Neu-Yilik G, et al. (2005). "Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.". Mol. Cell 20 (1): 65-75. doi:10.1016/j.molcel.2005.08.012. PMID 16209946.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Andersen CB, Ballut L, Johansen JS, et al. (2006). "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.". Science 313 (5795): 1968-72. doi:10.1126/science.1131981. PMID 16931718.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.