MAGI3

From Wikipedia, the free encyclopedia

Membrane associated guanylate kinase, WW and PDZ domain containing 3

Identifiers

MAGI3; MAGI-3; MGC163281; RP4-730K3.1; dJ730K3.2

External IDs

MGI: 1923484 HomoloGene: 26431

Gene ontology
Molecular Function:	• guanylate kinase activity • protein binding • kinase activity
Cellular Component:	• membrane
Biological Process:	• apoptosis • intracellular signaling cascade

Orthologs

Human

Mouse

Refseq

NM_020965 (mRNA)
NP_066016 (protein)

NM_133853 (mRNA)
NP_598614 (protein)

Location

Chr 1: 113.73 - 114.03 Mb

Chr 3: 104.14 - 104.35 Mb

Pubmed search

[1]

[2]

Membrane associated guanylate kinase, WW and PDZ domain containing 3, also known as MAGI3, is a human gene.^[1]

[edit] References

^ Entrez Gene: MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3.

[edit] Further reading

Zhang H, Wang D, Sun H, et al. (2007). "MAGI-3 regulates LPA-induced activation of Erk and RhoA.". Cell. Signal. 19 (2): 261-8. doi:10.1016/j.cellsig.2006.06.008. PMID 16904289.
He J, Bellini M, Inuzuka H, et al. (2006). "Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins.". J. Biol. Chem. 281 (5): 2820-7. doi:10.1074/jbc.M509503200. PMID 16316992.
Franklin JL, Yoshiura K, Dempsey PJ, et al. (2005). "Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein.". Exp. Cell Res. 303 (2): 457-70. doi:10.1016/j.yexcr.2004.10.007. PMID 15652357.
Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap.". Oncogene 23 (36): 6023-30. doi:10.1038/sj.onc.1207817. PMID 15195140.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Adamsky K, Arnold K, Sabanay H, Peles E (2003). "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins.". J. Cell. Sci. 116 (Pt 7): 1279-89. PMID 12615970.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765.
Thomas M, Laura R, Hepner K, et al. (2002). "Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation.". Oncogene 21 (33): 5088-96. doi:10.1038/sj.onc.1205668. PMID 12140759.
Laura RP, Ross S, Koeppen H, Lasky LA (2002). "MAGI-1: a widely expressed, alternatively spliced tight junction protein.". Exp. Cell Res. 275 (2): 155-70. doi:10.1006/excr.2002.5475. PMID 11969287.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273-81. PMID 10997877.
Wu Y, Dowbenko D, Spencer S, et al. (2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.". J. Biol. Chem. 275 (28): 21477-85. doi:10.1074/jbc.M909741199. PMID 10748157.