MAGI1

From Wikipedia, the free encyclopedia

Membrane associated guanylate kinase, WW and PDZ domain containing 1

PDB rendering based on 2i04.

Available structures: 2i04

Identifiers

Symbol(s)

MAGI1; BAP1; AIP3; BAIAP1; MAGI-1; TNRC19; WWP3

External IDs

OMIM: 602625 MGI: 1203522 HomoloGene: 31257

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding • protein C-terminus binding • kinase activity • transferase activity
Cellular Component:	• plasma membrane • tight junction
Biological Process:	• protein complex assembly • cell adhesion • cell surface receptor linked signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001033057 (mRNA)
NP_001028229 (protein)

NM_001029850 (mRNA)
NP_001025021 (protein)

Location

Chr 3: 65.32 - 66 Mb

Chr 6: 93.64 - 94.25 Mb

Pubmed search

[1]

[2]

Membrane associated guanylate kinase, WW and PDZ domain containing 1, also known as MAGI1, is a human gene.^[1]

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1.

[edit] Further reading

Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets.". J. Biol. Chem. 272 (23): 14611–6. PMID 9169421.
Margolis RL, Abraham MR, Gatchell SB, et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain.". Hum. Genet. 100 (1): 114–22. PMID 9225980.
Dobrosotskaya I, Guy RK, James GL (1998). "MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains.". J. Biol. Chem. 272 (50): 31589–97. PMID 9395497.
Wood JD, Yuan J, Margolis RL, et al. (1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.". Mol. Cell. Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.
Shiratsuchi T, Futamura M, Oda K, et al. (1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1.". Biochem. Biophys. Res. Commun. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739.
Dobrosotskaya IY, James GL (2000). "MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures.". Biochem. Biophys. Res. Commun. 270 (3): 903–9. doi:10.1006/bbrc.2000.2471. PMID 10772923.
Patrie KM, Drescher AJ, Goyal M, et al. (2001). "The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes.". J. Am. Soc. Nephrol. 12 (4): 667–77. PMID 11274227.
Dobrosotskaya IY (2001). "Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1.". Biochem. Biophys. Res. Commun. 283 (4): 969–75. doi:10.1006/bbrc.2001.4880. PMID 11350080.
Laura RP, Ross S, Koeppen H, Lasky LA (2002). "MAGI-1: a widely expressed, alternatively spliced tight junction protein.". Exp. Cell Res. 275 (2): 155–70. doi:10.1006/excr.2002.5475. PMID 11969287.
Patrie KM, Drescher AJ, Welihinda A, et al. (2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.". J. Biol. Chem. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ohno H, Hirabayashi S, Kansaku A, et al. (2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains.". Oncogene 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hruska-Hageman AM, Benson CJ, Leonard AS, et al. (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
Wright GJ, Leslie JD, Ariza-McNaughton L, Lewis J (2005). "Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development.". Development 131 (22): 5659–69. doi:10.1242/dev.01417. PMID 15509766.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Mizuhara E, Nakatani T, Minaki Y, et al. (2005). "MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface.". J. Biol. Chem. 280 (28): 26499–507. doi:10.1074/jbc.M500375200. PMID 15908431.
Patrie KM (2005). "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1.". Biochim. Biophys. Acta 1745 (1): 131–44. doi:10.1016/j.bbamcr.2005.05.011. PMID 16019084.
Bratt A, Birot O, Sinha I, et al. (2005). "Angiomotin regulates endothelial cell-cell junctions and cell motility.". J. Biol. Chem. 280 (41): 34859–69. doi:10.1074/jbc.M503915200. PMID 16043488.
Sakurai A, Fukuhara S, Yamagishi A, et al. (2006). "MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion.". Mol. Biol. Cell 17 (2): 966–76. doi:10.1091/mbc.E05-07-0647. PMID 16339077.