MAGEA9

From Wikipedia, the free encyclopedia

Melanoma antigen family A, 9

Identifiers

MAGEA9; MAGE9; MGC8421

External IDs

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• cellular_component
Biological Process:	• biological_process

Orthologs

Human

Mouse

Entrez

4108

n/a

Refseq

NM_005365 (mRNA)
NP_005356 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Melanoma antigen family A, 9, also known as MAGEA9, is a human gene.^[1]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAGEA9 melanoma antigen family A, 9.

[edit] Further reading

Oehlrich N, Devitt G, Linnebacher M, et al. (2005). "Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma.". Int. J. Cancer 117 (2): 256-64. doi:10.1002/ijc.21200. PMID 15900605.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lee JH, Sung BW, Youn HJ, Park JH (2001). "Identification, expression, and nuclear location of murine Mage-b2 protein, a tumor-associated antigen.". Mol. Cells 10 (6): 647-53. PMID 11211869.
Serrano A, Lethé B, Delroisse JM, et al. (1999). "Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries.". Int. J. Cancer 83 (5): 664-9. PMID 10521804.
Timms KM, Bondeson ML, Ansari-Lari MA, et al. (1997). "Molecular and phenotypic variation in patients with severe Hunter syndrome.". Hum. Mol. Genet. 6 (3): 479-86. PMID 9147653.
Rogner UC, Wilke K, Steck E, et al. (1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28.". Genomics 29 (3): 725-31. doi:10.1006/geno.1995.9945. PMID 8575766.
De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family.". Immunogenetics 40 (5): 360-9. PMID 7927540.