Mad1

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MAD1 mitotic arrest deficient-like 1 (yeast)
PDB rendering based on 1go4.
Available structures: 1go4
Identifiers
Symbol(s)	MAD1L1; MAD1; HsMAD1; PIG9; TP53I9; TXBP181
External IDs	OMIM: 602686 MGI: 1341857 HomoloGene: 74500
Gene ontology Molecular Function: • molecular_function Cellular Component: • nucleus • centrosome • spindle Biological Process: • mitotic metaphase • mitotic anaphase • mitotic telophase • cell cycle • mitotic cell cycle checkpoint • cell division
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	8379	17120
Ensembl	ENSG00000002822	ENSMUSG00000029554
Uniprot	Q9Y6D9	Q9WTX8
Refseq	NM_001013836 (mRNA) NP_001013858 (protein)	NM_010752 (mRNA) NP_034882 (protein)
Location	Chr 7: 1.82 - 2.24 Mb	Chr 5: 140.26 - 140.57 Mb
Pubmed search	[1]	[2]

MAD1 mitotic arrest deficient-like 1 (yeast), also known as MAD1L1, is a human gene.^[1]

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.^[1]

[edit] See also

• MAD2
• Hyperphosphorylation

[edit] References

1. ^ ^{a b} Entrez Gene: MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast).