m7G(5')pppN diphosphatase

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In enzymology, a m7G(5')pppN diphosphatase (EC 3.6.1.30) is an enzyme that catalyzes the chemical reaction

7-methylguanosine 5'-triphospho-5'-polynucleotide + H₂O $\rightleftharpoons$ 7-methylguanosine 5'-phosphate + polynucleotide

Thus, the two substrates of this enzyme are 7-methylguanosine 5'-triphospho-5'-polynucleotide and H₂O, whereas its two products are 7-methylguanosine 5'-phosphate and polynucleotide.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase. Other names in common use include decapase, and m7G(5')pppN pyrophosphatase.

[edit] References

IUBMB entry for 3.6.1.30
BRENDA references for 3.6.1.30 (Recommended.)
PubMed references for 3.6.1.30
PubMed Central references for 3.6.1.30
Google Scholar references for 3.6.1.30
Lavers GC (1977). "Cleavage of pm7G from mRNA 5' terminal cap structures by pyrophosphatase activity in embryonic chick lens cells". Mol. Biol. Rep. 3: 413–20. doi:10.1007/BF00808382. PMID 593271.
Nuss DL, Altschuler RE, Peterson AJ (1982). "Purification and characterization of the m7G(5')pppN-pyrophosphatase from human placenta". J. Biol. Chem. 257: 6224–30. PMID 6122684.
Nuss DL, Furuichi Y (1977). "Characterization of the m7G(5')pppN-pyrophosphatase activity from HeLa cells". J. Biol. Chem. 252: 2815–21. PMID 16003.