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| Lysine riboswitch |
 |
| Type: |
Cis-reg; riboswitch; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Wickiser JK, Barrick JE |
| Avg length: |
182.2 nucleotides |
| Avg identity: |
49% |
|
The Lysine riboswitch is a metabolite binding RNA element found within certain messenger RNAs that serve as a precision sensor for the amino acid lysine. Allosteric rearrangement of mRNA structure is mediated by ligand binding, and this results in modulation of gene expression.[1] This riboswitches is found in a number of genes involved in lysine metabolism, including lysC.[2][3] The lysine riboswitch has also been identified independently and called the L box.[4]
[edit] References
- ^ Mandal, M; Boese B, Barrick JE, Winkler WC, Breaker RR (2003). "Riboswitches Control Fundamental Biochemical Pathways in Bacillus subtilis and Other Bacteria". Cell 113: 577–586. doi:10.1016/S0092-8674(03)00391-X. PMID 12787499.
- ^ Sudarsan, N; Wickiser JK, Nakamura S, Ebert MS, Breaker RR (2003). "An mRNA structure in bacteria that controls gene expression by binding lysine". Genes Dev 17: 2688–2697. doi:10.1101/gad.1140003. PMID 14597663.
- ^ Rodionov, DA; Vitreschak AG, Mironov AA, Gelfand MS (2003). "Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?". Nucleic Acids Res 31: 6748–6757. doi:10.1093/nar/gkg900. PMID 14627808.
- ^ Grundy, FJ; Lehman SC, Henkin TM (2003). "The L box regulon: Lysine sensing by leader RNAs of bacterial lysine biosynthesis genes". Proc Natl Acad Sci U S A 100: 12057–12062. doi:10.1073/pnas.2133705100. PMID 14523230.
[edit] External links
