Lymphotoxin alpha

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Lymphotoxin alpha (TNF superfamily, member 1)
PDB rendering based on 1tnr.
Available structures: 1tnr
Identifiers
Symbol(s)	LTA; LT; TNFB; TNFSF1
External IDs	OMIM: 153440 MGI: 104797 HomoloGene: 497
Gene ontology Molecular Function: • cysteine-type endopeptidase activity • cytokine activity • tumor necrosis factor receptor binding Cellular Component: • extracellular space • membrane Biological Process: • proteolysis • induction of apoptosis • immune response • humoral immune response • signal transduction • cell-cell signaling • lymph node development
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	4049	16992
Ensembl	ENSG00000204496	ENSMUSG00000024402
Uniprot	P01374	Q542S2
Refseq	NM_000595 (mRNA) NP_000586 (protein)	NM_010735 (mRNA) NP_034865 (protein)
Location	Chr 6: 31.65 - 31.65 Mb	Chr 17: 34.81 - 34.81 Mb
Pubmed search	[1]	[2]

Lymphotoxin alpha (TNF superfamily, member 1), also known as LTA, is a human gene.

Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.^[1]

[edit] See also

• Lymphotoxin

[edit] References

[edit] Further reading