LST1

From Wikipedia, the free encyclopedia

Leukocyte specific transcript 1

Identifiers

LST1; B144; D6S49E; LST-1; MGC119006; MGC119007

External IDs

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• cytoplasm • Golgi apparatus • membrane • integral to membrane
Biological Process:	• cell morphogenesis • immune response • regulation of cell shape • dendrite development • negative regulation of lymphocyte proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_007161 (mRNA)
NP_009092 (protein)

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n/a (protein)

Location

Chr 6: 31.66 - 31.66 Mb

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Pubmed search

[1]

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Leukocyte specific transcript 1, also known as LST1, is a human gene.^[1]

[edit] References

^ Entrez Gene: LST1 leukocyte specific transcript 1.

[edit] Further reading

Abraham LJ, Grimsley G, Zhang WJ, et al. (1992). "Polymorphism in the human B144 gene in different MHC haplotypes.". Eur. J. Immunogenet. 19 (3): 165–8. PMID 1352700.
Holzinger I, de Baey A, Messer G, et al. (1995). "Cloning and genomic characterization of LST1: a new gene in the human TNF region.". Immunogenetics 42 (5): 315–22. PMID 7590964.
Nalabolu SR, Shukla H, Nallur G, et al. (1997). "Genes in a 220-kb region spanning the TNF cluster in human MHC.". Genomics 31 (2): 215–22. doi:10.1006/geno.1996.0034. PMID 8824804.
de Baey A, Fellerhoff B, Maier S, et al. (1998). "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing.". Genomics 45 (3): 591–600. doi:10.1006/geno.1997.4963. PMID 9367684.
Pende D, Parolini S, Pessino A, et al. (1999). "Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells.". J. Exp. Med. 190 (10): 1505–16. PMID 10562324.
Neville MJ, Campbell RD (2000). "Alternative splicing of the LST-1 gene located in the Major Histocompatibility Complex on human chromosome 6.". DNA Seq. 8 (3): 155–60. PMID 10668961.
Rollinger-Holzinger I, Eibl B, Pauly M, et al. (2000). "LST1: a gene with extensive alternative splicing and immunomodulatory function.". J. Immunol. 164 (6): 3169–76. PMID 10706707.
Yu X, Weissman SM (2000). "Characterization of the promoter of human leukocyte-specific transcript 1. A small gene with a complex pattern of alternative transcripts.". J. Biol. Chem. 275 (44): 34597–608. doi:10.1074/jbc.M004700200. PMID 10944527.
Raghunathan A, Sivakamasundari R, Wolenski J, et al. (2001). "Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells.". Exp. Cell Res. 268 (2): 230–44. doi:10.1006/excr.2001.5290. PMID 11478849.
Ferlazzo G, Tsang ML, Moretta L, et al. (2002). "Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells.". J. Exp. Med. 195 (3): 343–51. PMID 11828009.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Castriconi R, Cantoni C, Della Chiesa M, et al. (2003). "Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4120–5. doi:10.1073/pnas.0730640100. PMID 12646700.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. PMID 14667819.
Harrison RE, Sikorski BA, Jongstra J (2005). "Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton.". J. Cell. Sci. 117 (Pt 10): 2151–7. doi:10.1242/jcs.00955. PMID 15090600.
Marafioti T, Mancini C, Ascani S, et al. (2006). "Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin's disease.". Haematologica 89 (8): 957–64. PMID 15339679.
Mulcahy H, O'Rourke KP, Adams C, et al. (2006). "LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection.". Immunogenetics 57 (12): 893–903. doi:10.1007/s00251-005-0057-2. PMID 16362817.