LRIG1

From Wikipedia, the free encyclopedia


Leucine-rich repeats and immunoglobulin-like domains 1
Identifiers
Symbol(s) LRIG1; LIG1; DKFZP586O1624; LIG-1
External IDs OMIM: 608868 MGI: 107935 HomoloGene: 7380
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 26018 16206
Ensembl ENSG00000144749 ENSMUSG00000030029
Uniprot Q96JA1 P70193
Refseq NM_015541 (mRNA)
NP_056356 (protein)		 NM_008377 (mRNA)
NP_032403 (protein)
Location Chr 3: 66.51 - 66.63 Mb Chr 6: 94.57 - 94.67 Mb
Pubmed search [1] [2]

Leucine-rich repeats and immunoglobulin-like domains 1, also known as LRIG1, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1.

[edit] Further reading

  • Suzuki Y, Sato N, Tohyama M, et al. (1996). "cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains.". J. Biol. Chem. 271 (37): 22522-7. PMID 8798419. 
  • Nilsson J, Vallbo C, Guo D, et al. (2001). "Cloning, characterization, and expression of human LIG1.". Biochem. Biophys. Res. Commun. 284 (5): 1155-61. doi:10.1006/bbrc.2001.5092. PMID 11414704. 
  • Suzuki Y, Miura H, Tanemura A, et al. (2002). "Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.". FEBS Lett. 521 (1-3): 67-71. PMID 12067728. 
  • Hedman H, Nilsson J, Guo D, Henriksson R (2002). "Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?". Acta oncologica (Stockholm, Sweden) 41 (4): 352-4. PMID 12234026. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nilsson J, Starefeldt A, Henriksson R, Hedman H (2004). "LRIG1 protein in human cells and tissues.". Cell Tissue Res. 312 (1): 65-71. doi:10.1007/s00441-003-0697-1. PMID 12684867. 
  • Thomasson M, Hedman H, Guo D, et al. (2003). "LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT--PCR and immunohistochemical analysis.". Br. J. Cancer 89 (7): 1285-9. doi:10.1038/sj.bjc.6601208. PMID 14520461. 
  • Gur G, Rubin C, Katz M, et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.". EMBO J. 23 (16): 3270-81. doi:10.1038/sj.emboj.7600342. PMID 15282549. 
  • Laederich MB, Funes-Duran M, Yen L, et al. (2004). "The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases.". J. Biol. Chem. 279 (45): 47050-6. doi:10.1074/jbc.M409703200. PMID 15345710. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ljuslinder I, Malmer B, Golovleva I, et al. (2006). "Increased copy number at 3p14 in breast cancer.". Breast Cancer Res. 7 (5): R719-27. doi:10.1186/bcr1279. PMID 16168117. 
  • Jensen KB, Watt FM (2006). "Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.". Proc. Natl. Acad. Sci. U.S.A. 103 (32): 11958-63. doi:10.1073/pnas.0601886103. PMID 16877544. 
  • Shattuck DL, Miller JK, Laederich M, et al. (2007). "LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy.". Mol. Cell. Biol. 27 (5): 1934-46. doi:10.1128/MCB.00757-06. PMID 17178829. 
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