LRCH4

From Wikipedia, the free encyclopedia

Leucine-rich repeats and calponin homology (CH) domain containing 4

Identifiers

LRCH4; FLJ40101; FLJ46315; LRN; LRRN1; LRRN4; PP14183; SAP25

External IDs

MGI: 1917193 HomoloGene: 20532

Gene ontology
Molecular Function:	• protein binding • transcription repressor activity
Cellular Component:	• cytoplasm • PML body
Biological Process:	• nervous system development • negative regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002319 (mRNA)
NP_002310 (protein)

NM_146164 (mRNA)
NP_666276 (protein)

Location

Chr 7: 100.01 - 100.02 Mb

Chr 5: 137.86 - 137.87 Mb

Pubmed search

[1]

[2]

Leucine-rich repeats and calponin homology (CH) domain containing 4, also known as LRCH4, is a human gene.^[1]

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor.^[1]

[edit] References

^ ^a ^b Entrez Gene: LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4.

[edit] Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Shiio Y, Rose DW, Aur R, et al. (2006). "Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.". Mol. Cell. Biol. 26 (4): 1386-97. doi:10.1128/MCB.26.4.1386-1397.2006. PMID 16449650.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Glöckner G, Scherer S, Schattevoy R, et al. (1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.". Genome Res. 8 (10): 1060-73. PMID 9799793.