LPIN1

From Wikipedia, the free encyclopedia

Lipin 1

Identifiers

LPIN1; DKFZp781P1796; KIAA0188

External IDs

OMIM: 605518 MGI: 1891340 HomoloGene: 9266

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• nucleus
Biological Process:	• lipid metabolic process • regulation of fat cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_145693 (mRNA)
NP_663731 (protein)

NM_015763 (mRNA)
NP_056578 (protein)

Location

Chr 2: 11.8 - 11.88 Mb

Chr 12: 16.56 - 16.64 Mb

Pubmed search

[1]

[2]

Lipin 1, also known as LPIN1, is a human gene.^[1]

This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism.^[1]

[edit] References

^ ^a ^b Entrez Gene: LPIN1 lipin 1.

[edit] Further reading

Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. PMID 8724849.
Péterfy M, Phan J, Oswell GM, et al. (2000). "Genetic, physical, and transcript map of the fld region on mouse chromosome 12.". Genomics 62 (3): 436–44. doi:10.1006/geno.1999.6023. PMID 10644441.
Reue K, Xu P, Wang XP, Slavin BG (2000). "Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene.". J. Lipid Res. 41 (7): 1067–76. PMID 10884287.
Péterfy M, Phan J, Xu P, Reue K (2001). "Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.". Nat. Genet. 27 (1): 121–4. doi:10.1038/83685. PMID 11138012.
Huffman TA, Mothe-Satney I, Lawrence JC (2002). "Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin.". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 1047–52. doi:10.1073/pnas.022634399. PMID 11792863.
Cao H, Hegele RA (2003). "Identification of single-nucleotide polymorphisms in the human LPIN1 gene.". J. Hum. Genet. 47 (7): 370–2. doi:10.1007/s100380200052. PMID 12111372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Suviolahti E, Reue K, Cantor RM, et al. (2006). "Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism.". Hum. Mol. Genet. 15 (3): 377–86. doi:10.1093/hmg/ddi448. PMID 16357106.
Han GS, Wu WI, Carman GM (2006). "The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme.". J. Biol. Chem. 281 (14): 9210–8. doi:10.1074/jbc.M600425200. PMID 16467296.
Finck BN, Gropler MC, Chen Z, et al. (2006). "Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.". Cell Metab. 4 (3): 199–210. doi:10.1016/j.cmet.2006.08.005. PMID 16950137.
Yao-Borengasser A, Rasouli N, Varma V, et al. (2006). "Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation.". Diabetes 55 (10): 2811–8. doi:10.2337/db05-1688. PMID 17003347.
van Harmelen V, Rydén M, Sjölin E, Hoffstedt J (2007). "A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.". J. Lipid Res. 48 (1): 201–6. doi:10.1194/jlr.M600272-JLR200. PMID 17035674.
Harris TE, Huffman TA, Chi A, et al. (2007). "Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.". J. Biol. Chem. 282 (1): 277–86. doi:10.1074/jbc.M609537200. PMID 17105729.
Croce MA, Eagon JC, LaRiviere LL, et al. (2007). "Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.". Diabetes 56 (9): 2395–9. doi:10.2337/db07-0480. PMID 17563064.