Talk:Lovastatin
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Curious about users and how you've reacted to this and other statins.
I've had nausea, vomiting, exercise intolerance, memory problems, depression.
I've stopped the med against MD orders and tried a second one (at MD's insistance) and only took one dose.
I'm only 50, and very concerned about long term on this and similar meds. I plan to live a very long life....so are these safe after 10 years? 20 years? longer?
(I'm also not too sure about this cholesterol = heart disease theorey.....but that's another discussion!)
Cindy
Statins may cause these side-effects. If you've tried all of them, you may be better off with a fibrate (they are also effective). If you do not believe the cholesterol/heart disease theory you're disagreeing with a rather hefty body of scientific research. I'm not sure if I would take the risk :-). I think the benefits of cholesterol lowering vastly outweigh the "risks" you are concerned about. Many people have been taking simvastatin since its discovery, and are probably still alive because of it, not despite it. JFW | T@lk 09:56, 28 Jan 2005 (UTC)
I'm concerned about taking these because Adicor's website says that it's not proven that their drug prevents cardiovascular disease or heart attacks. http://www.advicor.com/About_Advicor/What_Is_Advicor.asp Is there a statin that does have proof? Bob
[edit] Treating Neurofibromatosis I
There's some research to suggest that statin drugs may be effective in treating the cognitive problems associated with neurofibromatosis I. (At this point, just animal studies -- human trials are pending or in progress.) It may be worth watching for more information on this, and if the effect is confirmed by the scientific community, we should mention it here. Not yet, though. 66.67.222.16 15:20, 24 November 2006 (UTC)
[edit] Lovastatin and niacin
Re the statement in the article, "Lovastatin at doses higher than 20 mg per day should not be used in conjunction with gemfibrozil, niacin, cyclosporin, or other fibrates. This is because of the significantly increased risk of rhabdomyolysis": Advicor is a formulation of 40mg lovastatin with 1g time-released niacin (Niaspan) and the manufacturer does not mention this side effect on their Web site (http://www.advicor.com/About_Advicor/Advicor_Safety_Side_Effects.asp). Can we have an informed comment or edit of the entry? —Preceding unsigned comment added by Larrykoen (talk • contribs) 15:06, 8 September 2007 (UTC)
[edit] cholesterol and heart disease
It is now generally accepted that a major risk factor for the development of coronary heart disease is an elevated concentration of plasma cholesterol, especially low density lipoprotein (LDL) cholesterol. The objective is to decrease excess levels of cholesterol to an amount consistent with maintenance of normal body function.
—from the article
there's good evidence that chronic inflammation plays a key role in atherosclerosis, and that just lowering cholesterol does not stop this process. it turns out that statins inhibit inflammation, and this may be how they reduce the risk of congestive heart failure.
Duane Graveline wrote an informative book about statins, their effects on the body's cholesterol-based building blocks, and the widespread misunderstanding about cholesterol's role in atherosclerosis.
