Loganate O-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a loganate O-methyltransferase (EC 2.1.1.50) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + loganate S-adenosyl-L-homocysteine + loganin

Thus, the two substrates of this enzyme are S-adenosyl methionine and loganate, whereas its two products are S-adenosylhomocysteine and loganin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:loganate 11-O-methyltransferase. Other names in common use include loganate methyltransferase, and S-adenosyl-L-methionine:loganic acid methyltransferase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

[edit] References

• IUBMB entry for 2.1.1.50
• BRENDA references for 2.1.1.50 (Recommended.)
• PubMed references for 2.1.1.50
• PubMed Central references for 2.1.1.50
• Google Scholar references for 2.1.1.50
• Madyastha KM, Guarnaccia R, Baxter C, Coscia CJ (1973). "S-Adenosyl-L-methionine: loganic acid methyltransferase. A carboxyl-alkylating enzyme from Vinca rosea". J. Biol. Chem. 248: 2497–501. PMID 4698228. 

[edit] External links

The CAS registry number for this enzyme class is 39391-10-1.

• IUBMB entry for 2.1.1.50

• KEGG entry for 2.1.1.50

• BRENDA entry for 2.1.1.50

• NiceZyme view of 2.1.1.50

• EC2PDB: PDB structures for 2.1.1.50

• PRIAM entry for 2.1.1.50

• PUMA2 entry for 2.1.1.50

• IntEnz: Integrated Enzyme entry for 2.1.1.50

• MetaCyc entry for 2.1.1.50

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0030749: loganate O-methyltransferase

• AMIGO entry for GO code 0030749: loganate O-methyltransferase