LMO4

From Wikipedia, the free encyclopedia

LIM domain only 4

PDB rendering based on 1rut.

Available structures: 1rut, 2dfy

Identifiers

Symbol(s)

LMO4;

External IDs

OMIM: 603129 MGI: 109360 HomoloGene: 4927

Gene ontology
Molecular Function:	• transcription factor activity • transcription factor binding • zinc ion binding • metal ion binding
Cellular Component:	• transcription factor complex
Biological Process:	• neural tube closure • transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006769 (mRNA)
NP_006760 (protein)

NM_010723 (mRNA)
NP_034853 (protein)

Location

Chr 1: 87.57 - 87.59 Mb

Chr 3: 144.13 - 144.14 Mb

Pubmed search

[1]

[2]

LIM domain only 4, also known as LMO4, is a human gene.^[1]

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.^[1]

[edit] References

^ ^a ^b Entrez Gene: LMO4 LIM domain only 4.

[edit] Further reading

Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257-62. PMID 9736723.
Racevskis J, Dill A, Sparano JA, Ruan H (1999). "Molecular cloning of LMO41, a new human LIM domain gene.". Biochim. Biophys. Acta 1445 (1): 148-53. PMID 10209267.
Tse E, Grutz G, Garner AA, et al. (2000). "Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping.". Mamm. Genome 10 (11): 1089-94. PMID 10556429.
Sum EY, Peng B, Yu X, et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.". J. Biol. Chem. 277 (10): 7849-56. doi:10.1074/jbc.M110603200. PMID 11751867.
Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex.". J. Biomol. NMR 23 (2): 165-6. PMID 12153047.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Vu D, Marin P, Walzer C, et al. (2003). "Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells.". Brain Res. Mol. Brain Res. 115 (2): 93-103. PMID 12877980.
Manetopoulos C, Hansson A, Karlsson J, et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1.". Biochem. Biophys. Res. Commun. 307 (4): 891-9. PMID 12878195.
Sutherland KD, Visvader JE, Choong DY, et al. (2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas.". Int. J. Cancer 107 (1): 155-8. doi:10.1002/ijc.11343. PMID 12925972.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Novotny-Diermayr V, Lin B, Gu L, Cao X (2005). "Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction.". J. Biol. Chem. 280 (13): 12747-57. doi:10.1074/jbc.M500175200. PMID 15677447.
Sun T, Patoine C, Abu-Khalil A, et al. (2005). "Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.". Science 308 (5729): 1794-8. doi:10.1126/science.1110324. PMID 15894532.
Sum EY, Segara D, Duscio B, et al. (2005). "Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer.". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7659-64. doi:10.1073/pnas.0502990102. PMID 15897450.
Jeffries CM, Graham SC, Stokes PH, et al. (2007). "Stabilization of a binary protein complex by intein-mediated cyclization.". Protein Sci. 15 (11): 2612-8. doi:10.1110/ps.062377006. PMID 17001033.