Lipoyl(octanoyl) transferase

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In enzymology, a lipoyl(octanoyl) transferase (EC 2.3.1.181) is an enzyme that catalyzes the chemical reaction

octanoyl-[acyl-carrier-protein] + protein $\rightleftharpoons$ protein N₆-(octanoyl)lysine + acyl carrier protein

Thus, the two substrates of this enzyme are [[octanoyl-[acyl-carrier-protein]]] and protein, whereas its two products are protein N6-(octanoyl)lysine and acyl carrier protein.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase. Other names in common use include LipB, lipoyl (octanoyl)-[acyl-carrier-protein]-protein, N-lipoyltransferase, lipoyl (octanoyl)-acyl carrier protein:protein transferase, lipoate/octanoate transferase, lipoyltransferase, octanoyl-[acyl carrier protein]-protein N-octanoyltransferase, and lipoyl(octanoyl)transferase. This enzyme participates in lipoic acid metabolism.

[edit] References

IUBMB entry for 2.3.1.181
BRENDA references for 2.3.1.181 (Recommended.)
PubMed references for 2.3.1.181
PubMed Central references for 2.3.1.181
Google Scholar references for 2.3.1.181
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Jordan SW, Cronan JE Jr (1997). "A new metabolic link. The acyl carrier protein of lipid synthesis donates lipoic acid to the pyruvate dehydrogenase complex in Escherichia coli and mitochondria". J. Biol. Chem. 272: 17903–6. PMID 9218413.
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Wada M, Yasuno R, Jordan SW, Cronan JE Jr, Wada H (2001). "Lipoic acid metabolism in Arabidopsis thaliana: cloning and characterization of a cDNA encoding lipoyltransferase". Plant. Cell. Physiol. 42: 650–6. PMID 11427685.
Perham RN (2000). "Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions". Annu. Rev. Biochem. 69: 961–1004. PMID 10966480.