Lipid-A-disaccharide synthase

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In enzymology, a lipid-A-disaccharide synthase (EC 2.4.1.182) is an enzyme that catalyzes the chemical reaction

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate $\rightleftharpoons$ UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3- hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate

Thus, the two substrates of this enzyme are UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine and 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate, whereas its 3 products are UDP, 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-, and hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytet radecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase. This enzyme participates in lipopolysaccharide biosynthesis.

[edit] References

IUBMB entry for 2.4.1.182
BRENDA references for 2.4.1.182 (Recommended.)
PubMed references for 2.4.1.182
PubMed Central references for 2.4.1.182
Google Scholar references for 2.4.1.182
Crowell DN, Reznikoff WS, Raetz CR (1987). "Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase". J. Bacteriol. 169: 5727–34. PMID 2824445.
Ray BL, Painter G, Raetz CR (1984). "The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli". J. Biol. Chem. 259: 4852–9. PMID 6370995.