LIN7A

From Wikipedia, the free encyclopedia

Lin-7 homolog A (C. elegans)

PDB rendering based on 2dkr.

Available structures: 2dkr

Identifiers

Symbol(s)

LIN7A; LIN-7A; LIN7; MALS-1; MGC148143; TIP-33; VELI1

External IDs

OMIM: 603380 MGI: 2135609 HomoloGene: 20976

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• tight junction • membrane • basolateral plasma membrane • synaptosome • synapse
Biological Process:	• protein complex assembly • exocytosis • neurotransmitter secretion • protein transport • synaptic vesicle transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004664 (mRNA)
NP_004655 (protein)

NM_001033223 (mRNA)
NP_001028395 (protein)

Location

Chr 12: 79.72 - 79.86 Mb

Chr 10: 106.68 - 106.82 Mb

Pubmed search

[1]

[2]

Lin-7 homolog A (C. elegans), also known as LIN7A, is a human gene.^[1]

[edit] References

^ Entrez Gene: LIN7A lin-7 homolog A (C. elegans).

[edit] Further reading

Rousset R, Fabre S, Desbois C, et al. (1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.". Oncogene 16 (5): 643-54. doi:10.1038/sj.onc.1201567. PMID 9482110.
Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.". Cell 94 (6): 773-82. PMID 9753324.
Borg JP, Straight SW, Kaech SM, et al. (1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting.". J. Biol. Chem. 273 (48): 31633-6. PMID 9822620.
Borg JP, Lõpez-Figueroa MO, de Taddèo-Borg M, et al. (1999). "Molecular analysis of the X11-mLin-2/CASK complex in brain.". J. Neurosci. 19 (4): 1307-16. PMID 9952408.
Perego C, Vanoni C, Villa A, et al. (1999). "PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells.". EMBO J. 18 (9): 2384-93. doi:10.1093/emboj/18.9.2384. PMID 10228153.
Jo K, Derin R, Li M, Bredt DS (1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex.". J. Neurosci. 19 (11): 4189-99. PMID 10341223.
Kamberov E, Makarova O, Roh M, et al. (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7.". J. Biol. Chem. 275 (15): 11425-31. PMID 10753959.
Tseng TC, Marfatia SM, Bryant PJ, et al. (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain.". Biochim. Biophys. Acta 1518 (3): 249-59. PMID 11311936.
Harris BZ, Venkatasubrahmanyam S, Lim WA (2002). "Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes.". J. Biol. Chem. 277 (38): 34902-8. doi:10.1074/jbc.M205856200. PMID 12110687.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts.". FEBS Lett. 554 (1-2): 30-4. PMID 14596909.
Leonoudakis D, Conti LR, Radeke CM, et al. (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.". J. Biol. Chem. 279 (18): 19051-63. doi:10.1074/jbc.M400284200. PMID 14960569.
Leonoudakis D, Conti LR, Anderson S, et al. (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.". J. Biol. Chem. 279 (21): 22331-46. doi:10.1074/jbc.M400285200. PMID 15024025.
Olsen O, Wade JB, Morin N, et al. (2005). "Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney.". Am. J. Physiol. Renal Physiol. 288 (2): F345-52. doi:10.1152/ajprenal.00235.2004. PMID 15494546.
Dode L, Andersen JP, Raeymaekers L, et al. (2006). "Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses.". J. Biol. Chem. 280 (47): 39124-34. doi:10.1074/jbc.M506181200. PMID 16192278.
Bohl J, Brimer N, Lyons C, Vande Pol SB (2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions.". J. Biol. Chem. 282 (13): 9392-400. doi:10.1074/jbc.M610002200. PMID 17237226.