LIN28

From Wikipedia, the free encyclopedia

Lin-28 homolog (C. elegans)

PDB rendering based on 2cqf.

Available structures: 2cqf

Identifiers

Symbol(s)

LIN28; CSDD1; FLJ12457; LIN-28; LIN28A; ZCCHC1

External IDs

MGI: 1890546 HomoloGene: 32592

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • metal ion binding
Cellular Component:	• cytoplasm
Biological Process:	• regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024674 (mRNA)
NP_078950 (protein)

NM_145833 (mRNA)
NP_665832 (protein)

Location

Chr 1: 26.61 - 26.63 Mb

Chr 4: 133.28 - 133.29 Mb

Pubmed search

[1]

[2]

Lin-28 homolog (C. elegans), also known as LIN28, is a human gene.^[1] It is marker of undifferentiated human embryonic stem cells ^[2] and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. ^[3] It encodes a cytoplasmic mRNA-binding protein^[4] that binds to and enhances the translation of the Igf2 mRNA.^[5]. Lin28 has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells^[6].

[edit] References

^ Entrez Gene: LIN28 lin-28 homolog (C. elegans).
^ Richards M, et al. | The transcriptome profile of human embryonic stem cells as defined by SAGE. | Stem Cells 22:51-64, 2004 | PMID 14688391
^ Yu J, et al. | Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells | Science DOI: 10.1126/science.1151526 | PMID 18033853
^ Balzer E, Moss EG. | Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules.| RNA Biology 4:16-25, 2007.| PMID 17617744
^ Polesskaya A, et al. | Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency | Genes & Development 21:1125-1138, 2007 | PMID 17473174
^ Viswanathan S, et al. Selective Blockade of MicroRNA Processing by Lin28 | Science 320:97-100, 2008 |

""Selective Blockade of MicroRNA Processing by Lin28"" (2008). Science 320: 98–100.

[edit] Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Moss EG, Tang L (2003). "Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites.". Dev. Biol. 258 (2): 432–42. PMID 12798299.
Richards M, Tan SP, Tan JH, et al. (2004). "The transcriptome profile of human embryonic stem cells as defined by SAGE.". Stem Cells 22 (1): 51–64. PMID 14688391.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sempere LF, Freemantle S, Pitha-Rowe I, et al. (2004). "Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation.". Genome Biol. 5 (3): R13. doi:10.1186/gb-2004-5-3-r13. PMID 15003116.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gerecht-Nir S, Dazard JE, Golan-Mashiach M, et al. (2005). "Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells.". Dev. Dyn. 232 (2): 487–97. doi:10.1002/dvdy.20247. PMID 15614775.
Lee YS, Kim HK, Chung S, et al. (2005). "Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation.". J. Biol. Chem. 280 (17): 16635–41. doi:10.1074/jbc.M412247200. PMID 15722555.
Wu L, Belasco JG (2005). "Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells.". Mol. Cell. Biol. 25 (21): 9198–208. doi:10.1128/MCB.25.21.9198-9208.2005. PMID 16227573.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.