Limonene-1,2-epoxide hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a limonene-1,2-epoxide hydrolase (EC 3.3.2.8) is an enzyme that catalyzes the chemical reaction

limonene-1,2-epoxide + H₂O $\rightleftharpoons$ limonene-1,2-diol

Thus, the two substrates of this enzyme are limonene-1,2-epoxide and H₂O, whereas its product is limonene-1,2-diol.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is limonene-1,2-epoxide hydrolase. This enzyme is also called limonene oxide hydrolase. This enzyme participates in limonene and pinene degradation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1NU3, 1NWW, and 2BNG.

[edit] References

IUBMB entry for 3.3.2.8
BRENDA references for 3.3.2.8 (Recommended.)
PubMed references for 3.3.2.8
PubMed Central references for 3.3.2.8
Google Scholar references for 3.3.2.8
van der Werf MJ, Overkamp KM, de Bont JA (1998). "Limonene-1,2-epoxide hydrolase from Rhodococcus erythropolis DCL14 belongs to a novel class of epoxide hydrolases". J. Bacteriol. 180: 5052–7. PMID 9748436.
Barbirato F, Verdoes JC, de Bont JA, van der Werf MJ (1998). "The Rhodococcus erythropolis DCL14 limonene-1,2-epoxide hydrolase gene encodes an enzyme belonging to a novel class of epoxide hydrolases". FEBS. Lett. 438: 293–6. PMID 9827564.