LHX2

From Wikipedia, the free encyclopedia

LIM homeobox 2

PDB rendering based on 2dmq.

Available structures: 2dmq

Identifiers

Symbol(s)

LHX2; LH2; MGC138390; hLhx2

External IDs

OMIM: 603759 MGI: 96785 HomoloGene: 55848

Gene ontology
Molecular Function:	• transcription factor activity • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • nervous system development • brain development • mesoderm development • dorsal/ventral pattern formation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004789 (mRNA)
NP_004780 (protein)

XM_972881 (mRNA)
XP_977975 (protein)

Location

Chr 9: 125.81 - 125.84 Mb

Chr 2: 38.17 - 38.19 Mb

Pubmed search

[1]

[2]

LIM homeobox 2, also known as LHX2, is a human gene.^[1]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.^[1]

[edit] References

^ ^a ^b Entrez Gene: LHX2 LIM homeobox 2.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.". J. Biol. Chem. 274 (51): 36159-67. PMID 10593900.
Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.". Nat. Genet. 22 (4): 394-9. doi:10.1038/11970. PMID 10431247.
Rincón-Limas DE, Lu CH, Canal I, et al. (1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2165-70. PMID 10051612.
Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C (1998). "Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity.". Differentiation 63 (3): 151-7. PMID 9697309.
Wu HK, Heng HH, Siderovski DP, et al. (1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1.". Oncogene 12 (6): 1205-12. PMID 8649822.