LGALS4

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Lectin, galactoside-binding, soluble, 4 (galectin 4)
PDB rendering based on 1x50.
Available structures: 1x50
Identifiers
Symbol(s) LGALS4; GAL4
External IDs OMIM: 602518 MGI: 107536 HomoloGene: 21239
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3960 16855
Ensembl ENSG00000171747 n/a
Uniprot P56470 n/a
Refseq NM_006149 (mRNA)
NP_006140 (protein)		 NM_010706 (mRNA)
NP_034836 (protein)
Location Chr 19: 43.98 - 44 Mb n/a
Pubmed search [1] [2]

Lectin, galactoside-binding, soluble, 4 (galectin 4), also known as LGALS4, is a human gene.[1]

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS4 is an S-type lectin that is strongly underexpressed in colorectal cancer. The 323-amino acid LGALS4 protein contains 2 homologous, approximately 150-amino acid carbohydrate recognition domains and all amino acids typically conserved in galectins.[1]

[edit] References

  1. ^ a b Entrez Gene: LGALS4 lectin, galactoside-binding, soluble, 4 (galectin 4).

[edit] Further reading

  • Barondes SH, Cooper DN, Gitt MA, Leffler H (1994). "Galectins. Structure and function of a large family of animal lectins.". J. Biol. Chem. 269 (33): 20807-10. PMID 8063692. 
  • Huflejt ME, Jordan ET, Gitt MA, et al. (1997). "Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion.". J. Biol. Chem. 272 (22): 14294-303. PMID 9162064. 
  • Rechreche H, Mallo GV, Montalto G, et al. (1997). "Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer.". Eur. J. Biochem. 248 (1): 225-30. PMID 9310382. 
  • Ideo H, Seko A, Ohkura T, et al. (2002). "High-affinity binding of recombinant human galectin-4 to SO(3)(-)-->3Galbeta1-->3GalNAc pyranoside.". Glycobiology 12 (3): 199-208. PMID 11971864. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ideo H, Seko A, Yamashita K (2005). "Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells.". J. Biol. Chem. 280 (6): 4730-7. doi:10.1074/jbc.M410362200. PMID 15546874. 
  • Delacour D, Gouyer V, Zanetta JP, et al. (2005). "Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells.". J. Cell Biol. 169 (3): 491-501. doi:10.1083/jcb.200407073. PMID 15883199. 
  • Stowell SR, Karmakar S, Stowell CJ, et al. (2007). "Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells.". Blood 109 (1): 219-27. doi:10.1182/blood-2006-03-007153. PMID 16940423. 
  • Ideo H, Seko A, Yamashita K (2007). "Recognition mechanism of galectin-4 for cholesterol 3-sulfate.". J. Biol. Chem. 282 (29): 21081-9. doi:10.1074/jbc.M703770200. PMID 17545668. 
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