LGALS3BP

From Wikipedia, the free encyclopedia

Lectin, galactoside-binding, soluble, 3 binding protein

PDB rendering based on 1by2.

Available structures: 1by2

Identifiers

Symbol(s)

LGALS3BP; 90K; MAC-2-BP

External IDs

OMIM: 600626 MGI: 99554 HomoloGene: 4067

Gene ontology
Molecular Function:	• scavenger receptor activity • protein binding
Cellular Component:	• proteinaceous extracellular matrix • extracellular space • membrane
Biological Process:	• cellular defense response • cell adhesion • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_005567 (mRNA)
NP_005558 (protein)

NM_011150 (mRNA)
NP_035280 (protein)

Location

Chr 17: 74.48 - 74.49 Mb

Chr 11: 118.21 - 118.22 Mb

Pubmed search

[1]

[2]

Lectin, galactoside-binding, soluble, 3 binding protein, also known as LGALS3BP, is a human gene.^[1]

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.^[1]

[edit] References

^ ^a ^b Entrez Gene: LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein.

[edit] Further reading

Grassadonia A, Tinari N, Iurisci I, et al. (2004). "90K (Mac-2 BP) and galectins in tumor progression and metastasis.". Glycoconj. J. 19 (7-9): 551–6. doi:10.1023/B:GLYC.0000014085.00706.d4. PMID 14758079.
Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S (1991). "Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin.". J. Biol. Chem. 266 (28): 18731–6. PMID 1917996.
Yu B, Wright SD (1995). "LPS-dependent interaction of Mac-2-binding protein with immobilized CD14.". J. Inflamm. 45 (2): 115–25. PMID 7583357.
Calabrese G, Sures I, Pompetti F, et al. (1995). "The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25.". Cytogenet. Cell Genet. 69 (3-4): 223–5. PMID 7698018.
Ullrich A, Sures I, D'Egidio M, et al. (1994). "The secreted tumor-associated antigen 90K is a potent immune stimulator.". J. Biol. Chem. 269 (28): 18401–7. PMID 8034587.
Koths K, Taylor E, Halenbeck R, et al. (1993). "Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain.". J. Biol. Chem. 268 (19): 14245–9. PMID 8390986.
Inohara H, Akahani S, Koths K, Raz A (1996). "Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion.". Cancer Res. 56 (19): 4530–4. PMID 8813152.
Brakebusch C, Jallal B, Fusco O, et al. (1997). "Expression of the 90K immunostimulator gene is controlled by a promoter with unique features.". J. Biol. Chem. 272 (6): 3674–82. PMID 9013622.
Fusco O, Querzoli P, Nenci I, et al. (1998). "90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells.". Int. J. Cancer 79 (1): 23–6. PMID 9495353.
Sasaki T, Brakebusch C, Engel J, Timpl R (1998). "Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.". EMBO J. 17 (6): 1606–13. doi:10.1093/emboj/17.6.1606. PMID 9501082.
Trahey M, Weissman IL (1999). "Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 3006–11. PMID 10077627.
Tinari N, Kuwabara I, Huflejt ME, et al. (2001). "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation.". Int. J. Cancer 91 (2): 167–72. PMID 11146440.
Hellstern S, Sasaki T, Fauser C, et al. (2002). "Functional studies on recombinant domains of Mac-2-binding protein.". J. Biol. Chem. 277 (18): 15690–6. doi:10.1074/jbc.M200386200. PMID 11867635.
Marchetti A, Tinari N, Buttitta F, et al. (2002). "Expression of 90K (Mac-2 BP) correlates with distant metastasis and predicts survival in stage I non-small cell lung cancer patients.". Cancer Res. 62 (9): 2535–9. PMID 11980646.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Kristiansen TZ, Bunkenborg J, Gronborg M, et al. (2005). "A proteomic analysis of human bile.". Mol. Cell Proteomics 3 (7): 715–28. doi:10.1074/mcp.M400015-MCP200. PMID 15084671.