LGALS13

From Wikipedia, the free encyclopedia

Lectin, galactoside-binding, soluble, 13 (galectin 13)

Identifiers

LGALS13; GAL13; PLAC8; PP13

External IDs

Gene ontology
Molecular Function:	• lysophospholipase activity • carboxylesterase activity • sugar binding • hydrolase activity
Biological Process:	• phospholipid metabolic process • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_013268 (mRNA)
NP_037400 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 19: 44.79 - 44.79 Mb

n/a

Pubmed search

[1]

n/a

Lectin, galactoside-binding, soluble, 13 (galectin 13), also known as LGALS13, is a human gene.^[1]

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family.^[1]

[edit] References

^ ^a ^b Entrez Gene: LGALS13 lectin, galactoside-binding, soluble, 13 (galectin 13).

[edit] Further reading

Wang A, Dennis EA (1999). "Mammalian lysophospholipases.". Biochim. Biophys. Acta 1439 (1): 1-16. PMID 10395961.
Bohn H, Kraus W, Winckler W (1983). "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17).". Oncodev. Biol. Med. 4 (5): 343-50. PMID 6856484.
Than NG, Sumegi B, Than GN, et al. (1999). "Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden Crystal protein.". Placenta 20 (8): 703-10. doi:10.1053/plac.1999.0436. PMID 10527825.
Uhlmann J, Wiemann S, Ponstingl H (1999). "DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness.". FEBS Lett. 460 (1): 153-60. PMID 10571079.
Visegrády B, Than NG, Kilár F, et al. (2002). "Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13).". Protein Eng. 14 (11): 875-80. PMID 11742106.
Sjölinder M, Uhlmann J, Ponstingl H (2003). "DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion.". FEBS Lett. 532 (1-2): 211-5. PMID 12459492.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Than NG, Pick E, Bellyei S, et al. (2004). "Functional analyses of placental protein 13/galectin-13.". Eur. J. Biochem. 271 (6): 1065-78. PMID 15009185.
Burger O, Pick E, Zwickel J, et al. (2004). "Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies.". Placenta 25 (7): 608-22. doi:10.1016/j.placenta.2003.12.009. PMID 15193867.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Chafetz I, Kuhnreich I, Sammar M, et al. (2007). "First-trimester placental protein 13 screening for preeclampsia and intrauterine growth restriction.". Am. J. Obstet. Gynecol. 197 (1): 35.e1-7. doi:10.1016/j.ajog.2007.02.025. PMID 17618748.