Leucocyanidin oxygenase

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In enzymology, a leucocyanidin oxygenase (EC 1.14.11.19) is an enzyme that catalyzes the chemical reaction

leucocyanidin + 2-oxoglutarate + O₂ $\rightleftharpoons$ cis- and trans-dihydroquercetins + succinate + CO₂ + 2 H₂O

The 3 substrates of this enzyme are leucocyanidin, 2-oxoglutarate, and O₂, whereas its 5 products are cis-dihydroquercetin, trans-dihydroquercetin, succinate, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is leucocyanidin,2-oxoglutarate:oxygen oxidoreductase. This enzyme is also called anthocyanidin synthase. This enzyme participates in flavonoid biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2BRT.

[edit] References

IUBMB entry for 1.14.11.19
BRENDA references for 1.14.11.19 (Recommended.)
PubMed references for 1.14.11.19
PubMed Central references for 1.14.11.19
Google Scholar references for 1.14.11.19
Saito K, Kobayashi M, Gong Z, Tanaka Y, Yamazaki M (1999). "Direct evidence for anthocyanidin synthase as a 2-oxoglutarate-dependent oxygenase: molecular cloning and functional expression of cDNA from a red forma of Perilla frutescens". Plant. J. 17: 181–9. doi:10.1046/j.1365-313X.1999.00365.x. PMID 10074715.
Schofield CJ and Prescott AG (2000). "Are anthocyanidins the immediate products of anthocyanidin synthase?". Chem. Commun.: 2473–2474.