LASS2

From Wikipedia, the free encyclopedia

LAG1 homolog, ceramide synthase 2 (S. cerevisiae)

Identifiers

LASS2; L3; FLJ10243; MGC987; SP260; TMSG1

External IDs

OMIM: 606920 MGI: 1924143 HomoloGene: 41465

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus • endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• regulation of transcription, DNA-dependent • lipid biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013384 (mRNA)
NP_037516 (protein)

NM_029789 (mRNA)
NP_084065 (protein)

Location

Chr 1: 149.2 - 149.21 Mb

Chr 3: 95.4 - 95.41 Mb

Pubmed search

[1]

[2]

LAG1 homolog, ceramide synthase 2 (S. cerevisiae), also known as LASS2, is a human gene.^[1]

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: LASS2 LAG1 homolog, ceramide synthase 2 (S. cerevisiae).

[edit] Further reading

Pan H, Qin WX, Huo KK, et al. (2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.". Genomics 77 (1-2): 58–64. doi:10.1006/geno.2001.6614. PMID 11543633.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.". Mol. Cell Proteomics 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.