Large non-coding RNA

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There are a number of large non-coding RNAs in eukaryotes. These RNAs are mRNA-like (Pol II, spliced and polyadenylated) and perform regulatory roles.[1][2] Several have been characterised:

  • Xist and TSIX regulate X chromosome inactivation
  • AIR and H19 are paternal and maternal imprited genes which repress Igfr2 and igf2 on their respecive clusters, respectively
  • HOTAIR transcribed from HOXC cluster inhibits late HOXD
  • Evf
  • CTN
  • PINK
  • MIAT (Rncr2 in mouse)
  • MALAT1
  • HULC
  • HSR1
  • PCGEM1
  • BCYRN1(BC200; Bc1 in mouse)
  • HAR1A (HAR1F) & HAR1B (HAR1R)
  • ZFATAS (SAS-ZFAT)

[edit] References

  1. ^ Erdmann VA, Szymanski M, Hochberg A, Groot N, Barciszewski J (2000). "Non-coding, mRNA-like RNAs database Y2K". Nucleic Acids Res. 28 (1): 197–200. doi:10.1093/nar/28.1.197. PMID 10592224. 
  2. ^ Hüttenhofer A, Schattner P, Polacek N (2005). "Non-coding RNAs: hope or hype?". Trends Genet. 21 (5): 289–97. doi:10.1016/j.tig.2005.03.007. PMID 15851066. 
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